37118-71-1

Basic information

• Product Name: 3,4-diphenylquinolin-2(1H)-one
• Synonyms: 2(1H)-quinolinone, 3,4-diphenyl-
• CAS NO: 37118-71-1
• Molecular Formula: C₂₁H₁₅NO
• Molecular Weight: 297.3499
• Mol File: 37118-71-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 507.2°C at 760 mmHg
• Flash Point: 307.2°C
• Density: 1.206g/cm³
• Vapor Pressure: 2.08E-10mmHg at 25°C
• Refractive Index: 1.654
• CAS DataBase Reference: 3,4-diphenylquinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-diphenylquinolin-2(1H)-one(37118-71-1)
• EPA Substance Registry System: 3,4-diphenylquinolin-2(1H)-one(37118-71-1)

Safety Data

• Hazardous Substances Data: 37118-71-1(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 98952-64-8 N-ethoxycarbonyl-2-iodoaniline 
• 501-65-5 diphenyl acetylene 
• 61613-20-5 N-tosyl-2-iodoaniline 
• 143321-89-5 2,2,2-trifluoro-N-(2-iodophenyl)acetamide 
• 615-43-0 2-iodophenylamine 
• 342603-80-9 N-(2-benzoylphenyl)-2-phenylacetamide 
• 17282-99-4 3,4-diphenylquinoline 
• 622-79-7 benzyl azide 
• 100-39-0 benzyl bromide 
• 124-38-9 carbon dioxide 
• 19816-85-4 N'-(1,2-diphenylethylidene)-4-methylbenzenesulfonohydrazide 
• 42449-03-6 diphenylethanone p-toluenesulfonylhydrazone 
• 62-53-3 aniline 

Relevant articles and documents

Rh-catalyzed aerobic oxidative cyclization of anilines, alkynes, and CO

Transition-metal-catalyzed oxidative C-H cyclization of anilines has been an attractive and powerful strategy for the efficient construction of N-heterocycles. However, primary and tertiary anilines are rarely employed in this strategy due to the relative instability with strong oxidants or the presence of three C-N bonds. We describe here a novel Rh-catalyzed C-H cyclization of a wide range of anilines with alkynes and CO, using an aerobic oxidative protocol. Particularly, the simple primary anilines and readily prepared tertiary anilines could be easily converted to quinolin-2(1H)-ones, which are high value-added, biologically significant N-heterocycles, via C-N bond cleavage.

Palladium-Catalyzed Multi-Component Reactions of N-Tosylhydrazones, 2-Iodoanilines and CO2towards 4-Aryl-2-Quinolinones

A palladium-catalyzed three-component reaction between N-tosylhydrazones, 2-iodoanilines and atmospheric pressure CO2was developed whereby a tandem carbene migration insertion/lactamization strategy afforded 4-aryl-2-quinolinones in moderate to good yields. Notably, a wide range of functional groups were tolerated in this procedure. This protocol features the simultaneous formation of four novel bonds; two C?C, one C=C and one C?N (amide), representing an efficient methodology for incorporation of CO2into heterocycles.

Implications for selectivity of 3,4-diarylquinolinones as p38αMAP kinase inhibitors

In this study we report on the specificity profiling of the MAP kinase inhibitors 1, 2, and 3 in a panel of 78 protein kinases including the MAPK isoforms p38(α,β,γ,δ), JNK1/2/3, and ERK1/2/8 showing 3-(4-fluorophenyl)-4-pyridin-4-ylquinolin-2(1H)-one (1)