371194-86-4

Basic information

• Product Name: (5R)-3-(4-(3,6-dihydro-2H-pyran-4-yl)-3-fluorophenyl)-5-(2-oxo-2H-pyridaz-1-ylmethyl)oxazolidin-2-one
• Synonyms: (5R)-3-(4-(3,6-dihydro-2H-pyran-4-yl)-3-fluorophenyl)-5-(2-oxo-2H-pyridaz-1-ylmethyl)oxazolidin-2-one
• CAS NO: 371194-86-4
• Molecular Weight: 371.368
• Mol File: 371194-86-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (5R)-3-(4-(3,6-dihydro-2H-pyran-4-yl)-3-fluorophenyl)-5-(2-oxo-2H-pyridaz-1-ylmethyl)oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (5R)-3-(4-(3,6-dihydro-2H-pyran-4-yl)-3-fluorophenyl)-5-(2-oxo-2H-pyridaz-1-ylmethyl)oxazolidin-2-one(371194-86-4)
• EPA Substance Registry System: (5R)-3-(4-(3,6-dihydro-2H-pyran-4-yl)-3-fluorophenyl)-5-(2-oxo-2H-pyridaz-1-ylmethyl)oxazolidin-2-one(371194-86-4)

Safety Data

• Hazardous Substances Data: 371194-86-4(Hazardous Substances Data)

Upstream product

• 504-30-3 2H-Pyridazin-3-one 
• 188975-33-9 (R)-(-)-3-[3-fluoro-4-(3,6-dihydro-2H-pyran-4-yl)phenyl]-5-hydroxymethyl-2-oxazolidinone 

Relevant articles and documents

Oxazolidinone derivatives with antibiotic activity

Compounds of the formula (I), or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein HET is an N-linked 5-membered heteroaryl ring, optionally substituted on a C atom by an oxo or thioxo group; and/or by 1 or 2 (1-4C)alkyl groups; and/or on an available nitrogen atom by (1-4C)alkyl; or HET is an N-linked 6-membered heteroaryl ring containing up to three nitrogen heteroatoms in total, optionally substituted on a C atom as above; Q is selected from, for example, Q1 R2 and R3 are independently hydrogen or fluoro; T is selected from a range of groups, for example, of formula (TC5) wherein Rc is, for example, R13CO—, R13SO2— or R13CS—; wherein R13 is, for example, optionally substituted (1-10C)alkyl or R14C(O)O(1-6C)alkyl wherein R14 is optionally substituted (1-10C)alkyl; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.