504-30-3Relevant articles and documents
Infrared matrix isolation and ab initio studies of 3(2H)-pyridazinone and photoproduced 3-hydroxypyridazine
Lapinski, Leszek,Fulara, Jan,Czerminski, Ryszard,Nowak, Maciej J.
, p. 1087 - 1096 (1990)
The infrared spectra of 3(2H)-pyridazinone and its rare tautomeric form, 3-hydroxypyridazine, isolated in an argon matrix are reported and discussed.Only the first tautomer was observed after deposition of the matrix.The second form was photochemically pr
Synthetic method of pyridazinone
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Paragraph 0022-0031, (2021/03/30)
The invention relates to a new process for synthesizing pyridazinone, which is characterized in that C-TiO2 solid acid with a core-shell structure is used as a catalyst to replace traditional glacialacetic acid, tetramethyl ammonium bromide serves as a phase transfer catalyst, tert-butylhydrazine and furochloric acid are adopted to synthesize pyridazinone under certain conditions, the reaction efficiency is improved by adding the catalyst, and alkali washing and water washing processes are omitted, so that the yield and the quality of the product are improved, and the generation of three wastes is greatly reduced.
Ring-closing metathesis for the synthesis of heteroaromatics: evaluating routes to pyridines and pyridazines
Donohoe, Timothy J.,Bower, John F.,Basutto, José A.,Fishlock, Lisa P.,Procopiou, Panayiotis A.,Callens, Cedric K.A.
experimental part, p. 8969 - 8980 (2009/12/26)
Ring-closing olefin metathesis (RCM) has been applied to the efficient synthesis of densely and diversely substituted pyridine and pyridazine frameworks. Routes to suitable metathesis precursors have been investigated and the scope of the metathesis step has been probed. The metathesis products function as precursors to the target heteroaromatic structures via elimination of a suitable leaving group, which also facilitates earlier steps by serving as a protecting group at nitrogen. Further functionalisation of the metathesis products is possible both prior to and after aromatisation. The net result is a powerful strategy for the de novo synthesis of highly substituted heteroaromatic scaffolds.