88491-61-6 Usage
Description
Pyridazine, 3-bromo(9CI), also known as 3-Bromopyridine, is an organic compound that can undergo lithiation with LDA at low temperatures in the 4-position. It is involved in the formation of the Grignard reagent by Mg exchange with i-PrMgCl and in transmetallation of the lithiated derivative with zinc chloride followed by treatment with an electrophile, which is a route to 4-substituted 3-bromopyridines. It is also used as an intermediate in the synthesis of Active Pharmaceutical Ingredients, particularly Abiraterone acetate (an antiandrogen medication used in the treatment of prostate cancer) and Zimelidine (a selective serotonin reuptake inhibitor (SSRI) antidepressant).
Uses
Used in Pharmaceutical Industry:
Pyridazine, 3-bromo(9CI) is used as an intermediate in the synthesis of Active Pharmaceutical Ingredients for the development of various medications.
Used in Prostate Cancer Treatment:
Pyridazine, 3-bromo(9CI) is used as a precursor in the synthesis of Abiraterone acetate, an antiandrogen medication specifically used in the treatment of prostate cancer.
Used in Antidepressant Medication:
Pyridazine, 3-bromo(9CI) is used as a precursor in the synthesis of Zimelidine, a selective serotonin reuptake inhibitor (SSRI) antidepressant medication.
References
Jennifer A. Love Dr.; John P. Morgan.;Tina M. Trnka.;Robert H. Grubbs Prof. A Practical and Highly Active Ruthenium-Based Catalyst that Effects the Cross Metathesis of Acrylonitrile. Angewandte Chemie International Edition. 2002, 41 (21), 4035-4037.
Wenjie Li.; Dorian P. Nelson.; Mark S. Jensen.; R. Scott Hoerrner.; Dongwei Cai.; Robert D. Larsen.; Paul J. Reider. An Improved Protocol for the Preparation of 3-Pyridyland Some Arylboronic Acids. J. Org. Chem. 2002, 57 (16), 5394-5397.
https://www.alfa.com/en/catalog/A12894/
Cai, Dongwei, R. D. Larsen, and P. J. Reider. "Effective lithiation of 3-bromopyridine: synthesis of 3-pyridine boronic acid and variously 3-substituted pyridines." Cheminform 33.38(2002):4285-4287.
www.jubl.com/uploads/files/48msds_msds-3-bromopyridine.pdf
Check Digit Verification of cas no
The CAS Registry Mumber 88491-61-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,4,9 and 1 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 88491-61:
(7*8)+(6*8)+(5*4)+(4*9)+(3*1)+(2*6)+(1*1)=176
176 % 10 = 6
So 88491-61-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H3BrN2/c5-4-2-1-3-6-7-4/h1-3H
88491-61-6Relevant articles and documents
3-OXO-TETRAHYDRO-FURO[3,2-B]PYRROL-4(5H)-YL) DERIVATIVES I
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Page/Page column 68, (2015/11/16)
The invention relates to amidic oxotetrahydro-2H-furo[3.2-b]pyrrol-4(5H)-yl) derivatives as dual CatS/K inhibitors, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.