371771-11-8Relevant articles and documents
Process for the preparation of 2-halobenzoic acids
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, (2008/06/13)
The present invention provides a process for producing 2-halobenzoic acids of the general formula (I), characterized by reacting a benzoic acid of formula (II) with a halogenating agent in the presence of Pd catalyst: (wherein A is —OH, —OM (M is alkali metal), —N(R6)R7 (R6 and R7 are each H, C1-C6 alkyl, optionally substituted phenyl, or the like) ; R is H, C1-C6 alkyl, C1-C6 alkylcarbonyl, carboxyl, C1-C12 alkoxycarbonyl, optionally substituted phenylcarbonyl, or the like; n is 0 to 4; X is Cl, Br or I, or alternatively (R)n may be present on benzene-constituting carbon atoms adjacent to each other and form a C3-C4 alkylene- or C3-C4 alkenylene-fused ring).
