371943-69-0Relevant articles and documents
Development of a bioavailable boron-containing PI-103 Bioisostere, PI-103BE
Guo, Shanchun,He, Ling,Luo, Lan,Wang, Guangdi,Zhang, Changde,Zhang, Qiang,Zheng, Shilong,Zhong, Qiu
, (2020/05/22)
PI-103 (7) is a potent dual phosphatidylinositol 3-kinase (PI3K)/mTOR inhibitor, but its rapid in vivo metabolism hinders its further clinical development. To improve the bioavailability of PI-103, we designed and synthesized a PI-103 bioisostere, PI-103B