372159-76-7 Usage
General Description
3-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester, also known as tert-butyl 3-(2-oxoethyl)piperidine-1-carboxylate, is a chemical compound with the molecular formula C13H23NO3. It is a tert-butyl ester derivative of 3-(2-oxo-ethyl)-piperidine-1-carboxylic acid, and is commonly used in organic synthesis and drug research. 3-(2-OXO-ETHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is a white to off-white crystalline powder with a melting point of 64-67°C, and its Boiling point is 294.3°C at 760 mmHg. It is soluble in ethanol, chloroform and dimethyl sulfoxide, and is used as a building block in the synthesis of pharmaceutical compounds and other organic chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 372159-76-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,2,1,5 and 9 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 372159-76:
(8*3)+(7*7)+(6*2)+(5*1)+(4*5)+(3*9)+(2*7)+(1*6)=157
157 % 10 = 7
So 372159-76-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H21NO3/c1-12(2,3)16-11(15)13-7-4-5-10(9-13)6-8-14/h8,10H,4-7,9H2,1-3H3
372159-76-7Relevant articles and documents
NOVEL HISTONE METHYLTRANSFERASE INHIBITORS
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Page/Page column 30; 45-46, (2021/04/01)
The present invention relates to novel compounds of formula (I) as defined herein. The compounds are inhibitors of histone methyltransferases of the seven-beta-strand family, in particular of KMT9.
CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships.
Wacker, Dean A,Santella 3rd., Joseph B,Gardner, Daniel S,Varnes, Jeffrey G,Estrella, Melissa,DeLucca, George V,Ko, Soo S,Tanabe, Keiichi,Watson, Paul S,Welch, Patricia K,Covington, Maryanne,Stowell, Nicole C,Wadman, Eric A,Davies, Paul,Solomon, Kimberly A,Newton, Robert C,Trainor, George L,Friedman, Steven M,Decicco, Carl P,Duncia, John V
, p. 1785 - 1789 (2007/10/03)
CCR3 antagonist leads with IC(50) values in the microM range were converted into low nM binding compounds that displayed in vitro inhibition of human eosinophil chemotaxis induced by human eotaxin. In particular, 4-benzylpiperidin-1-yl-n-propylureas and erythro-3-(4-benzyl-2-(alpha-hydroxyalkyl)piperidin-1-yl)-n-propylureas (obtained via Beak reaction of N-BOC-4-benzylpiperidine) exhibited single digit nanomolar IC(50) values for CCR3.
