4606-65-9 Usage
Description
3-Piperidinemethanol, a white solid, is an organic compound with the molecular formula C6H13NO. It is characterized by the presence of a piperidine ring and a hydroxyl group, which contribute to its unique chemical properties and reactivity. This versatile compound has been studied for its standard molar energy of combustion, indicating its potential applications in various chemical and pharmaceutical processes.
Uses
Used in Pharmaceutical Industry:
3-Piperidinemethanol is used as a reactant for the synthesis of various pharmaceutical compounds, including:
1. CB2 receptor agonists for the treatment of chronic pain, which can provide relief by targeting the CB2 receptors in the body.
2. Spiroimidazolidinone NPC1L1 inhibitors, which are being investigated for their potential in treating conditions related to cholesterol transport and absorption.
3. Quorum sensing modulators, which can interfere with bacterial communication and have potential applications in combating antibiotic resistance.
4. Protein lysine methyltransferase G9a inhibitors, which are involved in epigenetic regulation and may have implications in the development of therapies for various diseases.
5. P2Y12 antagonists for inhibition of platelet aggregation, which can be used in the treatment of cardiovascular conditions, such as preventing blood clots.
6. Soluble epoxide hydrolase inhibitors, which have potential applications in treating inflammatory and cardiovascular diseases by modulating the balance of eicosanoids.
Check Digit Verification of cas no
The CAS Registry Mumber 4606-65-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,6,0 and 6 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4606-65:
(6*4)+(5*6)+(4*0)+(3*6)+(2*6)+(1*5)=89
89 % 10 = 9
So 4606-65-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H13NO/c8-5-6-2-1-3-7-4-6/h6-8H,1-5H2/p+1/t6-/m0/s1
4606-65-9Relevant articles and documents
Manganese Catalyzed Hydrogenation of Enantiomerically Pure Esters
Widegren, Magnus B.,Clarke, Matthew L.
supporting information, p. 2654 - 2658 (2018/05/17)
A manganese-catalyzed hydrogenation of esters has been accomplished with TONs up to 1000, using cheap, environmentally benign, potassium carbonate and simple alcohols as activator and solvent, respectively. The weakly basic conditions lead to good functional group tolerance and enable the hydrogenation of enantiomerically enriched α-chiral esters with essentially no loss of stereochemical integrity.
PROCESS FOR PREPARING ENANTIOMERICALLY ENRICHED 3-HYDROXYMETHYLPIPERIDINE
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Page/Page column 17, (2014/11/13)
The present invention relates to a process for preparing enantiomerically enriched 3-hydroxymethylpiperidine and in particular of the S-enantiomer of (S)-3-hydroxymethyl- piperidine in high chemical and optical purity. The invention also relates to extremely pure (S)-3-hydroxymethylpiperidine and (R)-3-hydroxymethylpiperidine.
FARNESYL PROTEIN TRANSFERASE INHIBITORS
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Page/Page column 33, (2010/02/11)
Disclosed are compounds of formula (1.0), wherein R represents a cyclic moiety to which is bound an imodazolylalkyl group; R represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
