3740-52-1Relevant articles and documents
Preparation method of phenylacetic acid type compound
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Paragraph 0119; 0120; 0121, (2019/02/21)
The invention discloses a preparation method of a phenylacetic acid type compound. The preparation method of the phenylacetic acid type compound I comprises the following steps that in a solvent and aCO gas phase system, a benzyl halide type compound II, pyridine-2-cobalt carboxylate, palladium acetate and alkaline neutralizers take carbonylation reaction to obtain the phenylacetic acid type compound I. A mixed catalytic system has a synergistic effect; the whole use quantity of catalysts is greatly reduced. When the mixed catalyst is used, a better catalytic effect can be achieved; the characteristics of easily obtaining the catalyst, avoiding the production safety risk of toxic three wastes and the like, reducing the reaction pressure, realizing mild reaction conditions, reducing the production risk, facilitating the production and the like are realized. The formulas are shown in description.
Synthesis method of O-nitrophenylacetic acid
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Paragraph 0008; 0010-0029, (2019/01/07)
The invention discloses a synthesis method of O-nitrophenylacetic acid; anhydrous ethanol, Pt-MgO-CNTs, metallic sodium, O-nitrotoluene, diethyl oxalate, hydrogen peroxide and H2PtCl6 are used as mainraw materials; according to the synthesis process, O-nitrotoluene and diethyl oxalate are subjected to condensation reaction under the action of the catalyst Pt-MgO-CNTs to obtain O-nitrophenylaceticacid; reduced pressure distillation replaces a separation method of water steam distillation, so the reaction time is greatly shortened and the separation effect is enhanced obviously. The optimum material ratio, oxidation reaction temperature and condensation reaction temperature and time are optimized through a large number of experiments, and the yield is greatly improved.
Total synthesis of bouchardatine
Naik, Nilesh H.,Urmode, Tukaram D.,Sikder, Arun K.,Kusurkar, Radhika S.
, p. 1112 - 1114 (2013/09/24)
Two new, efficient and simple routes using Heck-type reaction and intramolecular cyclization were developed for the synthesis of the naturally occurring cytotoxic alkaloid 2-(4-oxo-3,4-dihydroquinazolin-2-yl)-1H-indole-3- carbaldehyde (bouchardatine).
