37542-28-2

Basic information

• Product Name: methyl 2-(4-chlorophenyl)-2-oxoacetate
• Synonyms: methyl 2-(4-chlorophenyl)-2-oxoacetate
• CAS NO: 37542-28-2
• Molecular Weight: 198.606
• Mol File: 37542-28-2.mol
• Article Data: 47

Chemical Properties

• CAS DataBase Reference: methyl 2-(4-chlorophenyl)-2-oxoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(4-chlorophenyl)-2-oxoacetate(37542-28-2)
• EPA Substance Registry System: methyl 2-(4-chlorophenyl)-2-oxoacetate(37542-28-2)

Safety Data

• Hazardous Substances Data: 37542-28-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 27704-37-6 2,2,2-trichloro-1-(4-chlorophenyl)ethanone 
• 553-90-2 Dimethyl oxalate 
• 99-91-2 para-chloroacetophenone 
• 24091-92-7 methyl 2-bromo-2-(4-chlorophenyl)acetate 
• 18166-02-4 N-trimethylsilylmethylamine 
• 124-38-9 carbon dioxide 
• 75748-10-6 trimethyl-4-chlorobenzoylsilane 
• 13014-48-7 4-chlorobenzoyl cyanide 
• 40626-53-7 Dichloro-(4-chloro-phenyl)-acetonitrile 
• 140-53-4 p-chlorobenzyl cyanide 
• 74-88-4 methyl iodide 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 10399-10-7 methyl 2-(4-chlorophenyl)-2-methoxyacetate 

Downstream Products

• 63096-36-6 (4-chloro-phenyl)-hydroxy-acetic acid methyl ester 
• 32174-34-8 (4-chloro-phenyl)-hydroxy-acetic acid methyl ester 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 380610-20-8 2-(chlorophenyl)-3,3-dichloroacrylic acid methyl ester 
• 60300-84-7 methyl α-benzyloxyphenylacetate 
• 1616777-58-2 methyl 2-(4-chlorophenyl)-2-hydroxy-3-(2-phenyloxazol-5-yl)propanoate 
• 1644539-67-2 methyl (R)-2-(4-chlorophenyl)-5-oxo-3-phenyl-2,5-dihydrofuran-2-carboxylate 
• 1644539-86-5 methyl 2-(4-chlorophenyl)-5-oxo-3-phenyl-2,5-dihydrofuran-2-carboxylate 
• 1644539-71-8 methyl (R)-2-(4-chlorophenyl)-3-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-carboxylate 
• 1644539-90-1 methyl 2-(4-chlorophenyl)-3-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-carboxylate 
• 50415-79-7 methyl (E)-2-(4-chlorophenyl)-3-phenylprop-2-enoate 
• 151358-36-0 methyl (Z)-2-(4-chlorophenyl)-3-phenylprop-2-enoate 
• 7477-64-7 1-(p-chlorophenyl)-1,2-ethanediol 

Relevant articles and documents

Tris(pentafluorophenyl)borane-Catalyzed Oxygen Insertion Reaction of α-Diazoesters (α-Diazoamides) with Dimethyl Sulfoxide

A tris(pentafluorophenyl)borane-catalyzed oxidation reaction of α-diazoesters (α-diazo amides) with dimethyl sulfoxide has been developed. The reaction proceeds under metal free conditions to afford a series α-ketoesters and α-ketoamides. The synthetic utility of this protocol is demonstrated through synthetic transformations and scaled-up synthesis. (Figure presented.).

Visible-Light-Induced Catalyst-Free Carboxylation of Acylsilanes with Carbon Dioxide

Intermolecular carbon-carbon bond formation between acylsilanes and carbon dioxide (CO2) was achieved by photoirradiation under catalyst-free conditions. In this reaction, siloxycarbenes generated by photoisomerization of the acylsilanes added to the C═O bond of CO2 to give α-ketocarboxylates, which underwent hydrolysis to afford α-ketocarboxylic derivatives in good yields. Control experiments suggest that the generated siloxycarbene is likely to be from the singlet state (S1) of the acylsilane and the addition to CO2 is not in a concerted manner.

Tandem Photoredox-Chiral Phosphoric Acid Catalyzed Radical-Radical Cross-Coupling for Enantioselective Synthesis of 3-Hydroxyoxindoles

A photochemical protocol that couples diarylamines and α-ketoesters to afford the chiral 3-hydroxyoxindoles through tandem photoredox and chiral phosphoric acid catalysis is developed. The reaction involves an enantioselective photochemical radical-radical cross-coupling process. The chiral phosphoric acid is discovered to play crucial roles by decreasing the reductive potentials of α-ketoesters and stereocontrolling the downstream asymmetric radical-radical cross-coupling via the formation of pentacoordinate complex.