375844-31-8

Basic information

• Product Name: 4-Thiazoleaceticacid, 2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-,ethyl ester
• Synonyms: Ethyl2-[2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-1,3-thiazol-4-yl]acetate;Ethyl 2-[2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]thiazol-4-yl]acetate
• CAS NO: 375844-31-8
• Molecular Formula: C14H15 Cl N2 O4 S2
• Molecular Weight: 374.869
• Mol File: 375844-31-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Thiazoleaceticacid, 2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-,ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thiazoleaceticacid, 2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-,ethyl ester(375844-31-8)
• EPA Substance Registry System: 4-Thiazoleaceticacid, 2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-,ethyl ester(375844-31-8)

Safety Data

• Hazardous Substances Data: 375844-31-8(Hazardous Substances Data)

Upstream product

• 53266-94-7 ethyl 2-amino-1,3-thiazol-4-acetate 
• 80563-86-6 3-chloro-2-methylbenzenesulfonyl chloride 

Downstream Products

• 376638-09-4 [2-(3-chloro-2-methyl-benzenesulfonylamino)-thiazol-4-yl]-acetic acid 
• 376638-65-2 BVT-14225 

Relevant articles and documents

Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11β-hydroxysteroid dehydrogenase type 1

Novel antidiabetic arylsulfonamidothiazoles are presented that exert action through selective inhibition of the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme, thereby attenuating hepatic gluconeogenesis. The diethylamide derivative 2a was shown to potently inhibit human 11β-HSD1 (IC50 = 52 nM), whereas the N-methylpiperazinamide analogue 2b only inhibited murine 11β-HSD1 (IC50 = 96 nM). Both compounds showed >200-fold selectivity over human and murine 11β-HSD2. 2b was subsequently shown to reduce glucose levels in diabetic KKAy mice, substantiating the 11β-HSD1 enzyme as a target for the treatment of type 2 diabetes.