376581-24-7 Usage
Description
Quinoline-6-boronic acid is an organic compound that serves as a crucial building block in the synthesis of various organic molecules, pharmaceuticals, agrochemicals, and dyes. It is known for its unique chemical properties and reactivity, making it a valuable component in the development of new compounds and materials.
Uses
Used in Organic Synthesis:
Quinoline-6-boronic acid is used as a key intermediate for the synthesis of complex organic molecules. Its boronic acid functionality allows for versatile reactions, such as Suzuki-Miyaura cross-coupling, which is widely employed in the formation of carbon-carbon bonds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, quinoline-6-boronic acid is utilized as a starting material or intermediate in the development of new drugs. Its unique structure and reactivity enable the creation of novel therapeutic agents with potential applications in various medical fields.
Used in Agrochemicals:
Quinoline-6-boronic acid is also employed in the agrochemical industry as a building block for the synthesis of pesticides, herbicides, and other crop protection agents. Its incorporation into these compounds can lead to improved efficacy and selectivity, ultimately contributing to more effective and environmentally friendly agricultural practices.
Used in Dyestuff:
In the dyestuff industry, quinoline-6-boronic acid is used as a precursor for the synthesis of various dyes and pigments. Its ability to form a range of colored compounds makes it a valuable asset in the development of new colorants for various applications, including textiles, plastics, and printing inks.
Check Digit Verification of cas no
The CAS Registry Mumber 376581-24-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,6,5,8 and 1 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 376581-24:
(8*3)+(7*7)+(6*6)+(5*5)+(4*8)+(3*1)+(2*2)+(1*4)=177
177 % 10 = 7
So 376581-24-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H8BNO2/c12-10(13)8-3-4-9-7(6-8)2-1-5-11-9/h1-6,12-13H
376581-24-7Relevant articles and documents
Preparation method of benzoheterocyclic boric acid
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Paragraph 0062; 0064; 0066, (2018/09/13)
The invention provides a preparation method of benzoheterocyclic boric acid. The preparation method comprises steps as follows: (1) a benzoheterocyclic compound shown in a formula I is dissolved in asolvent A, a liquor A is obtained, a boronylation reagent is dissolved in a solvent B, a liquor B is obtained, a palladium catalyst and an alkaline reagent are immobilized on a channel of a continuousflow reactor, the liquor A and the liquor B are subjected to a continuous adding reaction, the reaction is stopped after the mixture flows out of a reaction tube, and an intermediate is obtained; (2)the intermediate obtained in step (1) is subjected to a hydrolysis reaction, and benzoheterocyclic boric acid is obtained. According to the provided preparation method, the benzoheterocyclic boric acid is synthesized with a flow chemical technology. Compared with methods in the prior art, the method has the advantages that the product yield is 86% or above, the highest yield can reach 90% or above, the yield is very high, the reaction rate is high, energy consumption of a reaction is reduced greatly, and the method is high in operability, high in automation degree and favorable for productionoperation and industrial production.
Flow Chemistry on Multigram Scale: Continuous Synthesis of Boronic Acids within 1 s
Hafner, Andreas,Meisenbach, Mark,Sedelmeier, Joerg
supporting information, p. 3630 - 3633 (2016/08/16)
The benefits and limitations of a simple continuous flow setup for handling and performing of organolithium chemistry on the multigram scale is described. The developed metalation platform embodies a valuable complement to existing methodologies, as it combines the benefits of Flash Chemistry (chemical synthesis on a time scale of 1 s) with remarkable throughput (g/min) while mitigating the risk of blockages.
