406463-06-7

Basic information

• Product Name: 6-Quinolineboronic acid pinacol ester, 97%
• Synonyms: 6-Quinolineboronic acid pinacol ester, 97%;6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline, 6-Quinolylboronic acid pinacol ester;Quinoline-6-boronic acid,pinacol ester;6-Quinolineboronic acid pinacol ester 97%
• CAS NO: 406463-06-7
• Molecular Formula: C₁₅H₁₈BNO₂
• Molecular Weight: 255.12
• Product Categories: Boronate Esters;Boronic Acids and Derivatives;Chemical Synthesis;Heteroaryl Boronate Esters;Organometallic Reagents
• Mol File: 406463-06-7.mol
• Article Data: 22

Chemical Properties

• Melting Point: 62-66 °C(lit.)
• Boiling Point: 386.5°C at 760 mmHg
• Flash Point: 187.5°C
• Appearance: White to pale orange/Powder or Crystalline Solid
• Density: 1.1g/cm³
• Vapor Pressure: 7.86E-06mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 6-Quinolineboronic acid pinacol ester, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Quinolineboronic acid pinacol ester, 97%(406463-06-7)
• EPA Substance Registry System: 6-Quinolineboronic acid pinacol ester, 97%(406463-06-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 406463-06-7(Hazardous Substances Data)

Usage

General Description

6-Quinolineboronic acid pinacol ester, 97% is a chemical compound with a purity of 97%. It is a boronic acid derivative of quinoline and is most commonly used in organic synthesis and medicinal chemistry. As a boronic acid, it can participate in various chemical reactions, including Suzuki-Miyaura cross-coupling reactions, making it a valuable tool in the construction of complex organic molecules. Additionally, its 97% purity ensures that it is suitable and reliable for use in research and industrial applications.

InChI:InChI=1/C15H18BNO2/c1-14(2)15(3,4)19-16(18-14)12-7-8-13-11(10-12)6-5-9-17-13/h5-10H,1-4H3

Upstream product

• 612-57-7 6-chloroquinoline 
• 73183-34-3 bis(pinacol)diborane 
• 5332-25-2 6-bromoquinoline 
• 1092513-18-2 quinolin-6-yl methanesulfonate 
• 580-16-5 6-hydroxyquinoline 
• 426265-40-9 quinolin-6-yl 4-methylbenzene-1-sulfonate 
• 106-40-1 4-bromo-aniline 
• 13327-31-6 6-iodoquinoline 
• 10349-57-2 Quinoline-6-carboxylic acid 
• 135808-70-7 1-(quinolin-6-yl)butan-1-one 

Downstream Products

• 1021915-68-3 1-(1-phenylethyl)-6-(quinolin-6-yl)-1H-imidazo[4,5-b]pyrazin-2(3H)-one 
• 1056882-02-0 3-quinolin-6-yl-cyclohex-2-enone 
• 1148008-66-5 N-[2-(ethyloxy)-5-(6-quinolinyl)-3-pyridinyl]benzenesulfonamide 
• 1201842-65-0 N-(2-chloro-5-(6-quinolinyl)-3-pyridinyl)-4-methoxybenzenesulfonamide 
• 1246888-99-2 1-(2-(quinolin-6-yl)phenyl)ethanone 
• 1366767-57-8 6-[4-(4-{[1-(cyclopropylcarbonyl)-3-azetidinyl]methyl}-4H-1,2,4-triazol-3-yl)-3-fluorophenyl] quinoline 
• 1404447-09-1 3-(4-fluorophenyl)-2-methyl-5-(quinolin-6-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1404447-10-4 3-(4-methoxyphenyl)-2-methyl-5-(quinolin-6-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1337933-01-3 C₂₆H₂₂N₂O₃S 
• 1454654-31-9 (4-morpholin-4-yl-phenyl)-(5-quinolin-6-yl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-amine 
• 376581-24-7 6-quinolineboronic acid 

Relevant articles and documents

Photocatalytic Cross-Couplings of Aryl Halides Enabled by o-Phosphinophenolate and o-Phosphinothiophenolate

o-Phosphinophenolate and o-phosphinothiophenolate are potent photocatalysts with strong reducing ability to activate aryl chlorides and bromides under visible light for borylation, arylation, and phosphorylation. Experimental and theoretical studies revealed that the o-diphenylphosphino substituent results in a narrow optical gap and facilitates intersystem crossing to access triplet states, which promote phenolate and thiophenolate to function as effective visible-light-photoredox catalysts. The results presented herein suggest promising utility of synthetically modified phenolates and thiophenolates as photoredox catalysts.

TRIAZOLO-PYRIMIDINE COMPOUNDS AND USES THEREOF

The present disclosure relates to novel triazolo-pyrimidine compounds targeting adenosine receptors (especially A1 and A2, particularly A2a). The present disclosure also relates to pharmaceutical compositions comprising one or more of the compounds as an active ingredient, and use of the compounds in the treatment of adenosine receptor (AR) associated diseases, for example cancer such as NSCLC, RCC, prostate cancer, and breast cancer.

1,2,4-TRIAZINE-3-AMINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE

The present invention relates to a 1,2,4-triazine-3-amine derivative, a preparation therefor, and use thereof in medicine. Specifically, the present invention relates to a 1,2,4-triazine-3-amine derivative as represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, and use thereof as a therapeutic agent, in particular as an A2a receptor antagonist, and use thereof in the preparation of a medicament for treating a condition or disorder that is ameliorated by means of inhibition of the A2a receptor, each substituent in general formula (I) being same as defined in the description.