37674-31-0Relevant articles and documents
A mild, convenient and efficient single-step method for the synthesis of polysubstituted furans via ammonium ylide routes
Fan, Mingjin,Guo, Lina,Liu, Xueyuan,Liu, Weimin,Liang, Yongmin
, p. 391 - 396 (2005)
A new and convenient cyclization method for the synthesis of polysubstituted furans in a single-step via ammonium ylide routes was reported. In this process, dimethyl acetylenedicarboxylate reacted with ammonium ylide to produce polysubstituted furan in the presence of anhydrous K2CO 3 at room temperature. It is very economical, environmentally friendly and very easy to carry out. Georg Thieme Verlag Stuttgart.
Regiospecific synthesis of polysubstituted furans with mono- to tricarboxylates from various sulfonium acylmethylides and acetylenic esters
Dong, Jun,Du, Hongguang,Xu, Jiaxi
, p. 25034 - 25038 (2019/08/22)
Polysubstituted furans were prepared in moderate to good yields from various sulfur ylides and alkyl acetylenic carboxylates. The direct reactions of dimethylsulfonium acylmethylides with dialkyl acetylenedicarboxylates afforded dialkyl furan-3,4-dicarboxylates through a tandem sequence of Michael addition, intramolecular nucleophilic addition, 4π ring opening, intramolecular Michael addition, and elimination. The method was extended to synthesize furan-3-carboxylate, -2,4-dicarboxylates, and -2,3,4-tricarboxylates as well. The current method provides a direct and simple strategy in the synthesis of structurally diverse polysubstituted furans with mono to tricarboxylate groups from safe and readily available dimethylsulfonium acylmethylides and different alkyl acetylenic carboxylates.
Regioselective friedel-crafts acylation with unsymmetrically substituted furandicarboxylic acid anhydride and furan acid chloride: Syntheses of 4-substituted 3-arylcarbonyl-2-phenylfuran and 3-substituted 4-arylcarbonyl-2-phenylfuran
Lin, Shrong-Shi,Nie, Xiao-Ping,Yu, Jun-Hua,Ye, Xiu-Lin
, p. 265 - 278 (2007/10/03)
Friedel-Crafts acylation of aromatic compounds with 2-phenylfuran-3,4-dicarboxylic acid anhydride (4) and 3-methoxycarbonyl-2-phenylfuran-4-carboxylic acid chloride (6) was studied. The reaction with 4, unsymmetrically substituted cyclic anhydrides, affor