4675-18-7

Basic information

• Product Name: 4,5-Diphenyloxazole
• Synonyms: 4,5-Diphenyloxazole;Oxazole, 4,5-diphenyl-
• CAS NO: 4675-18-7
• Molecular Formula: C₁₅H₁₁NO
• Molecular Weight: 221.25
• Mol File: 4675-18-7.mol
• Article Data: 11

Chemical Properties

• Melting Point: 44°C
• Boiling Point: 362.31°C (rough estimate)
• Appearance: /
• Density: 1.0966 (rough estimate)
• Refractive Index: 1.6283 (estimate)
• CAS DataBase Reference: 4,5-Diphenyloxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Diphenyloxazole(4675-18-7)
• EPA Substance Registry System: 4,5-Diphenyloxazole(4675-18-7)

Safety Data

• Hazardous Substances Data: 4675-18-7(Hazardous Substances Data)

Usage

General Description

4,5-Diphenyloxazole is a fluorescent organic compound that is often used as a scintillator in the detection of high-energy particles such as X-rays and gamma rays. It is particularly useful in the field of radiation detection and medical imaging due to its high sensitivity to ionizing radiation. This molecule absorbs the energy from incoming radiation and re-emits it as visible light, making it a valuable tool in the development of sensitive and accurate radiation detection systems. In addition to its applications in radiation detection, 4,5-Diphenyloxazole is also used as a fluorescent dye in biological and chemical research, as well as in the production of plastic scintillators for use in radiation detectors. Despite being a synthetic compound, it has established itself as an essential tool in various scientific and industrial applications.

Upstream product

• 82027-51-8 2-oxo-1,2-diphenylethyl formate 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 77287-34-4 formamide 
• 447-31-4 Desyl chloride 
• 540-69-2 ammonium formate 
• 93-58-3 benzoic acid methyl ester 
• 88333-03-3 Benzyl isocyanide 
• 92-71-7 2,5-diphenyloxazole 
• 14725-35-0 2-methylthio-4,5-diphenyl-1,3-oxazole 
• 76665-01-5 C-benzoyl-C-phenyl-N-methylthiomethyl Z-nitrone 
• 7664-93-9 sulfuric acid 
• 151-50-8 potassium cyanide 
• 97195-28-3 N-(2-oxo-1,2-diphenylethyl)formamide 
• 16712-16-6 ammonium formate 

Downstream Products

• 56157-49-4 (4,5-diphenyl-oxazol-2-yl)-phenyl-methanol 
• 14003-70-4 3-methyl-4,5-diphenyl-oxazolium; iodide 
• 92424-92-5 4,5-bis-(4-nitro-phenyl)-oxazole 
• 92555-39-0 4,4'-oxazole-4,5-diyl-bis-benzenesulfonamide 
• 4410-14-4 2-phenylphenanthro[9,10-d]oxazole 
• 92438-28-3 5-(4-nitro-phenyl)-4-phenyl-oxazole 
• 40046-88-6 N-((4-methoxyphenyl)carbamoyl)benzamide 
• 58328-35-1 N-benzoyl-N',N'-diethylurea 
• 126193-85-9 2,5-dimethoxy-4,5-diphenyl-3-oxazoline 
• 126193-85-9 2,5-dimethoxy-4,5-diphenyl-3-oxazoline 
• 37674-31-0 Dimethyl 2-phenylfuran-3,4-dicarboxylate 
• 4252-31-7 N-formylbenzamide 
• 102368-34-3 4,5-diphenyl-oxazole-2-carbaldehyde 
• 917988-94-4 (E)-3-(4,5-diphenyloxazol-2-yl)acrylaldehyde 

Relevant articles and documents

Fast-Synthesis of α-Phosphonyloxy Ketones as Drug Scaffolds in a Capillary Microreactor

A simple, room temperature approach for the fast single-step synthesis of α-phosphonyloxy ketone, a drug scaffold, has been developed which involves highly reactive species i.e., 1,2-dicarbonyls that readily react with trialkyl phosphites and formic acids in batch as well as in continuous-flow with the flow rate of 3 ml/min (tR = ～4 s). The present approach reduced the synthesis time from hours to minutes in batch, which was further lowered to a few seconds precisely controlled by single capillary microfluidics. A wide range of 1,2-dicarbonyl derivatives were smoothly transformed to their corresponding α-phosphonyloxy ketones in moderate to good yields (50–82 %) under optimized flow-reaction conditions. Further, the α-phosphonyloxy ketones produced can be utilized in batch process to form benzoin, oxazole core, and α,α′-diarylated carbonyl compounds in 82 %, 50 %, and 54 % yields, respectively, which are alternative key precursors/scaffolds of natural products and active pharmaceutical ingredients (APIs).

A method for the reductive scission of heterocyclic thioethers

A mild, chemoselective, and generally high-yielding method for the reductive scission of heterocyclic thioethers is described. Suitable heterocycles have a thioether substituent at the 2-position relative to a ring heteroatom. The convenient and straightforward method is demonstrated with reactants which are not compatible with the standard Raney nickel conditions such as sulfides, sulfones, and thiophenes. In addition, benzyl esters, benzyl amides, and benzyl carbamates are tolerated by the reductive reaction conditions.

Synthesis of azirines containing aldehyde functionality and their utilization as synthetic tools for five membered oxazoles and isoxazoles

(Chemical Equation Presented) A simple and useful procedure for the synthesis of azirines containing aldehyde functionality from open chain bromo/chloro-aldehydes at room temperature is reported. The scope of the ring expansion reaction of a number of 3-s