377-38-8Relevant articles and documents
HIGHLY FLUORINATED HETEROCYCLES. PART XVI. POLYFLUORINATED DERIVATIVES OF 1-METHYLPYRROLIDINE, 1-METHYLPYRROL-3-INE AND 1-METHYLPYRROLE
Coe, Paul L.,Holton, Andrew G.,Sleigh, John H.,Smith, Peter,Tatlow, John Colin
, p. 287 - 298 (1983)
Fluorination of 1-methylpyrrole with cobalt(III) fluoride gave six major products, 1-fluoromethyl- and 1-difluoromethyl- -octa-,-3H-hepta-, and -3H,4H-hexa-fluoropyrrolidine.Similar fluorination of 1-methyl-pyrrolidine gave better total recoveries of the same six products, together with 1-trifluoromethyloctafluoropyrrolidine, and 1-fluoromethyl- and 1-difluoromethyl- -2H-heptafluoropyrrolidine. 1-Fluoromethyl- and 1-difluoromethyl- -3H-heptafluoropyrrolidine each gave the corresponding polyfluoropyrrol-3-ine on dehydrofluorination with potassium hydroxide, but the 1-difluoromethyl-2H-heptafluoride could not be dehydrofluorinated. 1-Methyl- and 1-fluoromethyl- -3H,4H-hexafluoropyrrolidine similarly gave the corresponding 3H-3-ine, but no pyrrole.Reaction of 1-methyl-3H,4H-hexafluoropyrrolidine with 'old' aluminium chloride gave a little 1-methyl-2,5-dichlorodifluoropyrrole, the only fluoropyrrole we have obtained so far.Freshly sublimed AlCl3 afforded 1-methyltetrachloropyrrole (obtained also from 1-methylpyrrole and sulphuryl chloride) : fluorination of this with KCo(III)F4 gave 1-methyl- and 1-fluoromethyl- -3,4-dichloro-tetrafluoropyrrol-3-ine.
Preparation method of fluorine-containing dicarboxylic acid
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Paragraph 0045-0047, (2020/07/12)
The invention discloses a preparation method of fluorine-containing dicarboxylic acid, which comprises: by using fluorine-containing cycloolefin as a raw material, performing oxidation with an oxidantunder the actions of a solvent and a catalyst to generate the corresponding fluorine-containing dicarboxylic acid. According to the method, a mixed solvent composed of the organic solvent and water is used as a solvent system of an oxidation reaction, the fluorine-containing cycloolefin is oxidized into corresponding fluorine-containing dicarboxylic acid by using the oxidant under the action of the catalyst, and the method has the characteristics of simple operation, stable process, safety, short reaction time, high yield and high product quality, and is suitable for large-scale production.
Method for preparing fluorine-containing binary acyl fluoride from fluorine-containing cycloolefin
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Paragraph 0054, (2020/07/13)
The invention discloses a method for preparing fluorine-containing diacyl fluoride from fluorine-containing cycloolefin, which comprises the following steps: A) oxidizing fluorine-containing cycloolefin serving as a raw material by using an oxidant under the action of a solvent and a catalyst to generate corresponding fluorine-containing dicarboxylic acid; B) under the action of a solvent and a catalyst, subjecting the fluorine-containing dicarboxylic acid prepared in the step A and a fluorination reaction reagent to a fluorination reaction to obtain fluorine-containing diacyl fluoride. The method comprises the following steps: carrying out oxidation reaction on the fluorine-containing cycloolefin to generate corresponding fluorine-containing dicarboxylic acid; directly fluorinating the fluorine-containing dicarboxylic acid into the corresponding fluorine-containing binary acyl fluoride under the action of an organic solvent and a Lewis acid catalyst. The organic solvent and the specific catalyst are adopted, and other conditions are matched, so that the generation of the corresponding acyl fluoride with high efficiency and high yield from the fluorine-containing cycloolefin can beeffectively promoted.