37772-60-4

Basic information

• Product Name: JATROPHAM
• Synonyms: 2H-Pyrrol-2-one, 1,5-dihydro-5-hydroxy-3-methyl-
• CAS NO: 37772-60-4
• Molecular Formula: C₅H₇NO₂
• Molecular Weight: 113.115
• Mol File: 37772-60-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 119-121 °C
• Boiling Point: 382.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.263±0.06 g/cm3(Predicted)
• PKA: 11.79±0.40(Predicted)
• CAS DataBase Reference: JATROPHAM(CAS DataBase Reference)
• NIST Chemistry Reference: JATROPHAM(37772-60-4)
• EPA Substance Registry System: JATROPHAM(37772-60-4)

Safety Data

• Hazardous Substances Data: 37772-60-4(Hazardous Substances Data)

Upstream product

• 75633-16-8 1-ethoxycarbonyl-5-methyl-1H-1,3-diazepine 
• 76336-69-1 5-Hydroxy-3-methyl-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid benzyl ester 

Downstream Products

• 50656-76-3 (R)-(-)-5-hydroxy-3-methyl-3-pyrrolin-2-one 

Relevant articles and documents

Studies on diazepines. XXIV. Reactions of monocyclic 1H-1,3-diazepines. (2). Photo-sensitized oxygenation

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SYNTHESIS OF (+/-)-JATROPHAM, AN ANTITUMOR ALKALOID FROM JATROPHA MACRORHIZA

The synthesis of jatropham, assigned as 5-hydroxy-3-methyl-3-pyrrolin-2-one 4, and of its 4-methyl isomer 14 is achieved utilizing an autoxidation of 2-furylcarbamates 2 and 11 as the key step.