50656-76-3

Basic information

• Product Name: Jatropham
• Synonyms: Jatropham;(5R)-1,5-Dihydro-5-hydroxy-3-methyl-2H-pyrrol-2-one;(5R)-1,5-Dihydro-5-hydroxy-3-methyl-2H-pyrrole-2-one;(5R)-3-Methyl-5-hydroxy-3-pyrroline-2-one
• CAS NO: 50656-76-3
• Molecular Formula: C5H7 N O2
• Molecular Weight: 113.11
• Mol File: 50656-76-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 382.5°C at 760 mmHg
• Flash Point: 185.1°C
• Appearance: /
• Density: 1.263g/cm³
• Vapor Pressure: 2E-07mmHg at 25°C
• Refractive Index: 1.533
• PKA: 11.79±0.40(Predicted)
• CAS DataBase Reference: Jatropham(CAS DataBase Reference)
• NIST Chemistry Reference: Jatropham(50656-76-3)
• EPA Substance Registry System: Jatropham(50656-76-3)

Safety Data

• Hazardous Substances Data: 50656-76-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H7NO2/c1-3-2-4(7)6-5(3)8/h2,4,7H,1H3,(H,6,8)/t4-/m1/s1

Upstream product

• 109028-41-3 jatropham 5-O-β-D-glucopyranoside 
• 37772-60-4 5-hydroxy-3-methyl-1,5-dihydropyrrol-2-one 
• 1072-87-3 citraconimide 
• 108-05-4 vinyl acetate 
• 616-02-4 citraconic acid anhydride 

Relevant articles and documents

First synthesis of (R)-(-)-5-hydroxy-3-methyl-3-pyrrolin-2-one (jatropham) by lipase-catalyzed kinetic resolution

Jatropham, (R)-(-)-5-hydroxy-3-methyl-3-pyrrolin-2-one, is synthesized in three steps from citraconic anhydride. Highly regioselective reduction of citraconimide gives racemic jatropham in high yield. Kinetic resolution of racemic jatropham using lipase is also described. (C) 1999 Elsevier Science Ltd.

JATROPHAM GLUCOSIDE FROM THE BULBS OF LILIUM HANSONII

From the methanolic extract of the fresh bulbs of Lilium hansonii, a new glucoside, jatropham 5-O-β-D-glucopyranoside, was isolated together with jatropham and (+/-)-5-O-methyljatropham. Key Word Index--Lilium hansonii; liliaceae; jatropham; jatropham 5-O-β-D-glucopyranoside; (+/-)-5-O-methyljatropham; antitumor alkaloid.