37774-78-0

Basic information

• Product Name: 2-CYANOBENZOPHENONE 97
• Synonyms: 2-CYANOBENZOPHENONE 97
• CAS NO: 37774-78-0
• Molecular Formula: C₁₄H₉NO
• Molecular Weight: 207.231
• Mol File: 37774-78-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 82-87 °C(lit.)
• Boiling Point: 407.5°Cat760mmHg
• Flash Point: 200.3°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 7.49E-07mmHg at 25°C
• Refractive Index: 1.616
• CAS DataBase Reference: 2-CYANOBENZOPHENONE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYANOBENZOPHENONE 97(37774-78-0)
• EPA Substance Registry System: 2-CYANOBENZOPHENONE 97(37774-78-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 37774-78-0(Hazardous Substances Data)

Usage

Description

2-Cyanobenzophenone, also known as 2-benzoylbenzonitrile, is a carbonyl-ene-nitrile compound with a monoclinic crystal structure belonging to the space group P21/c. It is known for its reactivity with furan to form corresponding adducts and its reduction under electrochemical conditions to produce various compounds.

Uses

Used in Chemical Synthesis:
2-Cyanobenzophenone is used as a key intermediate in the synthesis of various organic compounds, including 3-phenyl-3H-isobenzofuran-1-ylidenamine. Its unique reactivity with furan and its reduction under electrochemical conditions make it a valuable component in the preparation of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Cyanobenzophenone is used as a building block for the development of new drugs. Its ability to form adducts and undergo reduction reactions allows for the creation of diverse chemical structures with potential therapeutic applications.
Used in Material Science:
2-Cyanobenzophenone's unique crystal structure and reactivity make it a candidate for use in the development of new materials with specific properties. Its potential applications in material science could include the creation of novel polymers, coatings, or other advanced materials with tailored characteristics.

InChI:InChI=1/C14H9NO/c15-10-12-8-4-5-9-13(12)14(16)11-6-2-1-3-7-11/h1-9H

Upstream product

• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 5162-03-8 (2-chlorophenyl)(phenyl)methanone 
• 544-92-3 copper(I) cyanide 
• 2042-37-7 o-cyanobromobenzene 
• 98-88-4 benzoyl chloride 
• 13047-06-8 o-bromobenzophenone 
• 151-50-8 potassium cyanide 
• 342-62-1 2-benzoylbenzenediazonium tetrafluoroborate 
• 172732-52-4 o-cyanophenylboronic acid-1,3-propylene glycol ester 
• 85-52-9 2-Benzoylbenzoic acid 
• 931-97-5 1-hydroxy-1-cyclohexanecarbonitrile 
• 201230-82-2 carbon monoxide 
• 780-69-8 triethoxyphenylsilane 
• 36800-94-9 2-cyanophenyl 4-methylbenzenesulfonate 

Downstream Products

• 85-52-9 2-Benzoylbenzoic acid 
• 37462-53-6 N-(3-oxo-1-phenyl-isoindolin-1-yl)-formamide 
• 51925-13-4 1,3-diphenyl-1H-isoindol-1-ol 
• 500346-52-1 2-(α-hydroxy-benzhydryl)-benzophenone-imine 
• 22679-53-4 2-tert-butylbenzophenone 
• 92757-92-1 1-(2-cyanophenyl)-1-phenylethylene 
• 686719-30-2 2-(2-methoxy-1-phenylethenyl)benzonitrile 
• 66166-25-4 1,4-diphenylisoquinoline 
• 77988-87-5 1,4-diphenyl-3,4-dihydroisoquinoline 

Relevant articles and documents

Aromatization as an Impetus to Harness Ketones for Metallaphotoredox-Catalyzed Benzoylation/Benzylation of (Hetero)arenes

Herein we report ketones as feedstock materials in radical cross-coupling reactions under Ni/photoredox dual catalysis. In this approach, simple condensation first converts ketones into prearomatic intermediates that then act as activated radical sources for cross-coupling with aryl halides. Our strategy enables the direct benzylation/benzoylation of (hetero)arenes under mild reaction conditions with high functional group tolerance.

o-Acylbenzonitriles: Synthesis and Heterocyclization under Acid Hydrolysis of the Cyano Group

2-Cyanobenzophenones were synthesized by reaction of 2-bromobenzophenones with copper(I) cyanide in DMF, and their transformations involving acid hydrolysis of the cyano group were studied. Reactions of o-benzoylbenzonitriles with trifluoroacetic acid in

Carbonylative coupling of aryl tosylates/triflates with arylboronic acids under CO atmosphere

The carbonylative Suzuki-Miyaura reaction between aryl tosylates/triflates with arylboronic acid is herein reported, using base-free conditions and a balloon pressure of carbon monoxide. Under these conditions, unsymmetrical biaryl ketones were obtained in modest to excellent yields. This method was adapted to the synthesis of oxybenzone and ketoprofen in good yields under mild conditions.