686719-30-2

Basic information

• Product Name: Benzonitrile, 2-(2-methoxy-1-phenylethenyl)-
• CAS NO: 686719-30-2
• Molecular Formula: C16H13NO
• Molecular Weight: 235.285
• Mol File: 686719-30-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 2-(2-methoxy-1-phenylethenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 2-(2-methoxy-1-phenylethenyl)-(686719-30-2)
• EPA Substance Registry System: Benzonitrile, 2-(2-methoxy-1-phenylethenyl)-(686719-30-2)

Safety Data

• Hazardous Substances Data: 686719-30-2(Hazardous Substances Data)

Upstream product

• 873838-37-0 2-cyanophenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 17336-68-4 N'-(2-methoxy-1-phenylethylidene)-4-methylbenzenesulfonohydrazide 
• 2042-37-7 o-cyanobromobenzene 
• 37774-78-0 2-cyanobenzophenone 
• 4009-98-7 (methoxymethyl)triphenylphosphonium chloride 

Downstream Products

• 1721-82-0 1-methyl-4-phenylisoquinoline 
• 66166-25-4 1,4-diphenylisoquinoline 

Relevant articles and documents

Synthesis of polysubstituted isoquinolines through cross-coupling reactions with α-alkoxytosylhydrazones

A Pd-catalyzed cross-coupling reaction of α-alkoxytosylhydrazones with sulfonates derived from salicyl aldehydes gives rise to protected 1,5-dicarbonyl compounds. Treatment with ammonium hydroxide readily transforms these alkenes into isoquinolines with d

New synthesis of isoquinoline and 3,4-dihydroisoquinoline derivatives

A simple and efficient synthesis of isoquinoline and 3,4- dihydroisoquinoline derivatives is described. 1-Alkyl-(or aryl)isoquinoline and 1-isoquinolinamine derivatives were obtained by intramolecular cyclization of 2-(2-methoxyethenyl) benzonitriles initiated by the addition of alkyl(or aryl)lithiums and lithium dialkylamides to the nitrile carbons, respectively. Synthesis of 4-aryl-3,4-dihydroisoquinolines was achieved by reactions of 2-(1-arylethenyl)benzonitriles with organolithiums, followed by aqueous workup. Treatment of the reaction mixtures with electrophiles prior to aqueous workup allowed the synthesis of 4,4-disubstituted 3,4-dihydroisoquinolines.