37865-86-4

Basic information

• Product Name: 6-ethoxy-1H-indole
• Synonyms: 6-ethoxy-1H-indole;6-Ethoxyindole;1H-Indole,6-ethoxy-
• CAS NO: 37865-86-4
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.20044
• EINECS: 253-696-5
• Mol File: 37865-86-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 309 °C at 760 mmHg
• Flash Point: 113.3 °C
• Appearance: /
• Density: 1.132g/cm³
• Vapor Pressure: 0.0012mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-ethoxy-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-ethoxy-1H-indole(37865-86-4)
• EPA Substance Registry System: 6-ethoxy-1H-indole(37865-86-4)

Safety Data

• Hazardous Substances Data: 37865-86-4(Hazardous Substances Data)

Usage

General Description

6-Ethoxy-1H-indole is a chemical compound with the molecular formula C11H11NO and a molar mass of 173.21 g/mol. It is an organic compound that features an indole ring with an ethoxy group attached to the sixth position of the ring. 6-ethoxy-1H-indole is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has also been identified as a potential intermediate in the synthesis of various bioactive compounds. 6-Ethoxy-1H-indole has been the subject of research for its potential therapeutic applications and is of interest to the pharmaceutical industry due to its structural features and chemical properties.

InChI:InChI=1/C10H11NO/c1-2-12-9-4-3-8-5-6-11-10(8)7-9/h3-7,11H,2H2,1H3

Upstream product

• 103989-09-9 6-ethoxy-1H-indole-2-carboxylic acid 
• 2380-86-1 6-hydroxy-1H-indole 
• 75-03-6 ethyl iodide 
• 2042-14-0 4-methyl-5-nitrophenol 
• 102871-92-1 4-ethoxy-1-methyl-2-nitrobenzene 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 74-96-4 ethyl bromide 

Downstream Products

• 876738-20-4 C₂₁H₂₃N₃O₃S 

Relevant articles and documents

INHIBITORS OF HEXOKINASE AND METHODS OF USE THEREOF

Provided herein are substituted substituted heterocycles useful as inhibitors of the HKII enzyme. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention further provides medical uses of substituted heterocycles, for example, as antitumor agents.

Discovery of N-(4′-(indol-2-yl)phenyl)sulfonamides as novel inhibitors of HCV replication

A series of novel 2-phenylindole analogs were synthesized and evaluated for activity in subgenomic HCV replicon inhibition assays. Several compounds containing small alkyl sulfonamides on the phenyl ring exhibiting submicromolar EC50 values against the genotype 1b replicon were identified. Among these, compound 25d potently inhibited the 1b replicon (EC50 = 0.17 μM) with 147-fold selectivity with respect to cytotoxicity. Compound 25d was stable in the presence of human liver microsomes and had a good pharmacokinetic profile in rats with an IV half-life of 4.3 h and oral bioavailability (F) of 58%.