876738-20-4

Basic information

• Product Name: C₂₁H₂₃N₃O₃S
• CAS NO: 876738-20-4
• Molecular Weight: 397.498
• Mol File: 876738-20-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₃N₃O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₃N₃O₃S(876738-20-4)
• EPA Substance Registry System: C₂₁H₂₃N₃O₃S(876738-20-4)

Safety Data

• Hazardous Substances Data: 876738-20-4(Hazardous Substances Data)

Upstream product

• 1443382-64-6 C₁₃H₁₅BN₂O₃ 
• 906644-51-7 C₁₁H₁₀N₂O 
• 594-44-5 Ethanesulfonyl chloride 
• 37865-86-4 6-ethoxy-1H-indole 
• 102871-92-1 4-ethoxy-1-methyl-2-nitrobenzene 
• 2042-14-0 4-methyl-5-nitrophenol 

Relevant articles and documents

Discovery of N-(4′-(indol-2-yl)phenyl)sulfonamides as novel inhibitors of HCV replication

A series of novel 2-phenylindole analogs were synthesized and evaluated for activity in subgenomic HCV replicon inhibition assays. Several compounds containing small alkyl sulfonamides on the phenyl ring exhibiting submicromolar EC50 values against the genotype 1b replicon were identified. Among these, compound 25d potently inhibited the 1b replicon (EC50 = 0.17 μM) with 147-fold selectivity with respect to cytotoxicity. Compound 25d was stable in the presence of human liver microsomes and had a good pharmacokinetic profile in rats with an IV half-life of 4.3 h and oral bioavailability (F) of 58%.