380635-86-9

Basic information

• Product Name: N-{2-nitro-3,4-dimethylphenyl}acetamide
• Synonyms: N-{2-nitro-3,4-dimethylphenyl}acetamide
• CAS NO: 380635-86-9
• Molecular Formula: C₁₀H₁₂N₂O₃
• Molecular Weight: 208.21388
• Mol File: 380635-86-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-{2-nitro-3,4-dimethylphenyl}acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{2-nitro-3,4-dimethylphenyl}acetamide(380635-86-9)
• EPA Substance Registry System: N-{2-nitro-3,4-dimethylphenyl}acetamide(380635-86-9)

Safety Data

• Hazardous Substances Data: 380635-86-9(Hazardous Substances Data)

Upstream product

• 64823-23-0 3,4-Dimethyl-2-nitroanilin 
• 108-24-7 acetic anhydride 
• 40318-29-4 (3,4-dimethyl-phenyl)-carbamic acid ethyl ester 
• 847819-97-0 (3,4-dimethyl-2-nitro-phenyl)-carbamic acid ethyl ester 
• 2198-54-1 N-(3,4-dimethylphenyl)acetamide 
• 95-64-7 4-amino-o-xylene 

Downstream Products

• 64823-23-0 3,4-Dimethyl-2-nitroanilin 

Relevant articles and documents

Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: Definition of the structural determinants for enzyme inhibition

This paper describes the development of piperazine and 4-aminopiperidine carboxamides/carbamates supported on a pharmacogenic pyrroloquinoxaline scaffold as inhibitors of the endocannabinoid catabolizing enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). Structure-activity relationships and molecular modelling studies allowed the definition of the structural requirements for dual FAAH/MAGL inhibition and led to the identification of a small set of derivatives (compounds 5e, i, k, m) displaying a balanced inhibitory profile against both enzymes, with compound 5m being the frontrunner of the subset. Favorable calculated physico-chemical properties suggest further investigation for specific analogues.