64823-23-0

Basic information

• Product Name: 3,4-Dimethyl-2-nitrobenzenamine
• Synonyms: 2-Nitro-3,4-xylidine;3,4-Dimethyl-2-nitroaniline;3,4-Dimethyl-2-nitrobenzenamine
• CAS NO: 64823-23-0
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Mol File: 64823-23-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 63.5 °C
• Boiling Point: 313.6±37.0 °C(Predicted)
• Appearance: /
• Density: 1.220±0.06 g/cm3(Predicted)
• PKA: 0.58±0.10(Predicted)
• CAS DataBase Reference: 3,4-Dimethyl-2-nitrobenzenamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dimethyl-2-nitrobenzenamine(64823-23-0)
• EPA Substance Registry System: 3,4-Dimethyl-2-nitrobenzenamine(64823-23-0)

Safety Data

• Hazardous Substances Data: 64823-23-0(Hazardous Substances Data)

Upstream product

• 847819-97-0 (3,4-dimethyl-2-nitro-phenyl)-carbamic acid ethyl ester 
• 74319-98-5 3,4-Dimethyl-2-nitrobenzamid 
• 95-64-7 4-amino-o-xylene 
• 4315-13-3 3,4-Dimethyl-2-nitrobenzoesaeure 
• 74319-97-4 3,4-Dimethyl-2-nitrobenzoylchlorid 
• 619-04-5 3,4-dimethylbenzoic acid 
• 40318-29-4 (3,4-dimethyl-phenyl)-carbamic acid ethyl ester 
• 380635-86-9 acetic acid-(3,4-dimethyl-2-nitro-anilide) 
• 2198-54-1 N-(3,4-dimethylphenyl)acetamide 

Downstream Products

• 41927-01-9 3,4-dimethyl-o-phenylenediamine 
• 380635-86-9 acetic acid-(3,4-dimethyl-2-nitro-anilide) 
• 859492-92-5 toluene-4-sulfonic acid-(3,4-dimethyl-2-nitro-anilide) 
• 74319-99-6 3,4-Dimethyl-2-nitrobenzolsulfonylchlorid 
• 6972-71-0 4,5-dimethyl-2-nitrobenzenamine 
• 69557-55-7 4,5-dimethyl-1H-benzimidazole 
• 62192-75-0 2,4,5-trimethyl-1H-benzimidazole 
• 66555-71-3 acetic acid-(6-chloro-2,3-dimethyl-anilide) 
• 103796-76-5 3,4,N-trimethyl-2-nitro-aniline 
• 859492-99-2 toluene-4-sulfonic acid-(3,4,N-trimethyl-2-nitro-anilide) 
• 415910-51-9 2-[4-(3,4-dimethyl-2-nitroanilino)phenyl]ethanol 

Relevant articles and documents

Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: Definition of the structural determinants for enzyme inhibition

This paper describes the development of piperazine and 4-aminopiperidine carboxamides/carbamates supported on a pharmacogenic pyrroloquinoxaline scaffold as inhibitors of the endocannabinoid catabolizing enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). Structure-activity relationships and molecular modelling studies allowed the definition of the structural requirements for dual FAAH/MAGL inhibition and led to the identification of a small set of derivatives (compounds 5e, i, k, m) displaying a balanced inhibitory profile against both enzymes, with compound 5m being the frontrunner of the subset. Favorable calculated physico-chemical properties suggest further investigation for specific analogues.