381248-06-2 Usage
Description
5'-broMo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one, also known as 3-Bromo-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one, is a chemical compound with a unique molecular structure. It is characterized by the presence of a bromine atom at the 5' position, a phenyl group at the 1' position, and a bipyridin ring system. 5'-broMo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one is known for its potential applications in the pharmaceutical industry due to its chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
5'-broMo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one is used as an intermediate in the synthesis of Perampanel (P285522), an antiepileptic drug. It plays a crucial role in the development of this medication, which is designed to help control seizures and improve the quality of life for patients suffering from epilepsy. 5'-broMo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one's unique structure allows it to be a key component in the creation of Perampanel, making it an essential part of the pharmaceutical industry's efforts to combat epilepsy and related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 381248-06-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,8,1,2,4 and 8 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 381248-06:
(8*3)+(7*8)+(6*1)+(5*2)+(4*4)+(3*8)+(2*0)+(1*6)=142
142 % 10 = 2
So 381248-06-2 is a valid CAS Registry Number.
381248-06-2Relevant articles and documents
NOVEL PROCESS FOR THE PREPARATION OF PERAMPANEL AND ITS INTERMEDIATES THEREOF
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, (2016/10/04)
The present invention provides novel process for preparation of 3-(2-cyanophenyl)-5-(2- pyridyl)-1-phenyl-1,2-dihydropyridin-2-one, commonly known as perampanel having the formula I. The present invention also provides novel intermediate compound of formula VI and process for the preparation of intermediate compound of formula VI. The present invention also provides purification of perampanel.
A practical, laboratory-scale synthesis of Perampanel
McElhinny Jr., Charles J.,Carroll,Lewin, Anita H.
, p. 57 - 62 (2012/04/10)
The orally active, noncompetitive, selective AMPA receptor antagonist Perampanel, 2-[1,6-dihydro-6-oxo-1-phenyl-(2,3-bipyridin)-5-yl]benzonitrile, has been prepared from readily available, relatively inexpensive starting materials. The synthesis was carried out on a laboratory scale with no specialized equipment, and involved only two chromatographic purifications. Georg Thieme Verlag Stuttgart. New York.
CRYSTAL OF 1,2-DIHYDROPYRIDINE COMPOUND (TYPE IV)
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Page/Page column 4, (2009/04/24)
A crystal of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one characterized in having a diffraction peak at a diffraction angle (2θ±0.2°) of 15.4° in a powder X-ray diffraction or others.