38313-19-8

Basic information

• Product Name: N-cyclohexylpyrrolidine-1-carboxamide
• CAS NO: 38313-19-8
• Molecular Formula: C₁₁H₂₀N₂O
• Molecular Weight: 196.2893
• Mol File: 38313-19-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 383.8°C at 760 mmHg
• Flash Point: 185.9°C
• Density: 1.06g/cm³
• Vapor Pressure: 4.27E-06mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: N-cyclohexylpyrrolidine-1-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexylpyrrolidine-1-carboxamide(38313-19-8)
• EPA Substance Registry System: N-cyclohexylpyrrolidine-1-carboxamide(38313-19-8)

Safety Data

• Hazardous Substances Data: 38313-19-8(Hazardous Substances Data)

Usage

General Description

N-cyclohexylpyrrolidine-1-carboxamide, also known as CCPA, is a chemical compound widely used in scientific research as a selective agonist for the adenosine A1 receptor. It is a white, crystalline powder with a molecular formula of C11H20N2O and a molecular weight of 192.29 g/mol. CCPA has been shown to have potential applications in the treatment of cardiovascular diseases, neurological disorders, and cancer. Its unique pharmacological properties and low toxicity make it a valuable tool for studying the role of adenosine receptors in various biological processes. However, further research is needed to fully understand its potential therapeutic benefits and safety profile.

Upstream product

• 123-75-1 pyrrolidine 
• 108-91-8 cyclohexylamine 
• 124-38-9 carbon dioxide 
• 3173-53-3 Cyclohexyl isocyanate 
• 931-53-3 Cyclohexyl isocyanide 
• 25070-80-8 prop-2'-en-1'-yl cyclohexylcarbamate 
• 874394-02-2 2,2,2-trichloroethyl N-cyclohexylcarbamate 

Relevant articles and documents

Electronic Activity Tuning of Acyclic Guanidines for Lactide Polymerization

Novel aromatic guanidine-based organocatalysts for the ring-opening of l-lactide were synthesized and applied in comprehensive polymerization experiments and kinetic studies. The introduction of electronically active substituents led to a significant chan

Chemoselective isocyanide insertion into the N-H bond using iodine-DMSO: Metal-free access to substituted ureas

Insertion of isocyanides into the N-H bond gives access to many medicinally important and structurally diverse complex nitrogen-containing heterocycles. Although the transition metal catalyzed isocyanide insertion into the N-H bond is very common, polymerization of isocyanides in the presence of a transition metal and their strong coordination with metals are the common drawbacks. On the other hand, the inertness of most of the isocyanides towards amines in the absence of a metal catalyst has stymied the growth of the metal-free approach for isocyanide insertion into amines. As a result, only a handful of metal catalysed methods with limited substrate scopes have been reported for the synthesis of ureas via isocyanide insertion into amines and no metal-free version has been reported yet. Interestingly, chemoselective isocyanide insertion into amines has not been reported in the literature. We employed the I2-DMSO reagent system for the chemoselective synthesis of ureas, where isocyanides react with aliphatic amines only, while aromatic amines need a nucleophilic activator (DABCO) to facilitate the formation of ureas. This method gave direct and chemoselective access to ureas by evading the commonly used yet toxic isocyanates.

Super fast cobalt carbonyl-mediated synthesis of ureas

Fast cobalt carbonyl-mediated generation of ureas from primary amines was performed using high-density microwave irradiation. This enhanced method permitted the preparation of symmetrical ureas in good yields and unsymmetrical ureas in moderate yields. Th