383859-43-6Relevant articles and documents
Hybridization between "six-membered" nucleic acids: RNA as a universal information system
Kerremans, Luc,Schepers, Guy,Rozenski, Jef,Busson, Roger,Van Aerschot, Arthur,Herdewijn, Piet
, p. 4129 - 4132 (2001)
(Matrix Presented) Within the polyA:polyT recognition system, cross-pairing between several nucleic acids with a phosphorylated six-membered carbohydrate (mimic) as repeating unit in the backbone structure has been observed. All investigated nucleic acids (except for β-homo-DNA) hybridize with RNA, leaving RNA as a versatile biopolymer for informational transfer.
NOVEL AZABENZIMIDAZOLE TETRAHYDROPYRAN DERIVATIVES
-
Paragraph 0586, (2015/08/04)
Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPKactivated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.