152613-20-2 Usage
Description
1,5-Anhydro-4,6-O-benzylidene-3-deoxy-D-glucitol is a white to off-white solid that serves as a versatile synthetic intermediate in the field of organic chemistry. It is particularly useful in the preparation of various biologically relevant compounds, such as fluorescein-containing Mannitol and Glucitol derivatives, as well as sugar nucleotides.
Uses
Used in Biochemical Research:
1,5-Anhydro-4,6-O-benzylidene-3-deoxy-D-glucitol is used as a synthetic intermediate for the preparation of fluorescein-containing Mannitol and Glucitol derivatives. These derivatives serve as probes for DNA hybridization, which is a crucial technique in molecular biology and genetic research. The application reason is to facilitate the detection and analysis of specific DNA sequences, enabling the study of gene expression, mutation identification, and other genetic phenomena.
Used in Pharmaceutical Industry:
1,5-Anhydro-4,6-O-benzylidene-3-deoxy-D-glucitol is also used as a synthetic intermediate in the preparation of sugar nucleotides. Sugar nucleotides are essential building blocks in the synthesis of various biologically active molecules, including nucleic acids and glycoproteins. The application reason is to provide a foundation for the development of new drugs and therapeutic agents that target these biomolecules, potentially leading to novel treatments for a range of diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 152613-20-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,6,1 and 3 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 152613-20:
(8*1)+(7*5)+(6*2)+(5*6)+(4*1)+(3*3)+(2*2)+(1*0)=102
102 % 10 = 2
So 152613-20-2 is a valid CAS Registry Number.
152613-20-2Relevant articles and documents
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides
Verheggen,Van Aerschot,Toppet,Snoeck,Janssen,Balzarini,De Clercq,Herdewijn
, p. 2033 - 2040 (2007/10/02)
The synthesis of 1,5-anhydrohexitol nucleosides is described. These nucleoside analogues were obtained by alkylation of the heterocyclic bases with the tosylate 10 or by alkylation of the bases with the alcohol 12 under Mitsunobu conditions. The compounds were evaluated for antiviral and cytostatic activity. Highly selective activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) was noted for 1,5-anhydro-2,3-dideoxy-2- (5-iodouracil-1-yl)-D-arabino-hexitol 4b at a concentration of 0.07 μg/mL. This activity must be dependent on a specific phosphorylation by the virus- encoded thymidine kinase (TK), since compound 4b was inactive against TK- deficient mutants of HSV-1. The corresponding cytosine 4c and guanine 4e analogues showed activity against HSV-1, HSV-2, and other herpes viruses (i.e. cytomegalovirus, varicella-zoster virus) at concentrations well below the cytotoxicity threshold (2 and 20 μg/mL, respectively). At these concentrations, compounds 4c and 4e proved also inhibitory to the growth of human T-cells (i.e. MT-4, CEM, MOLT-4).
