38417-02-6

Basic information

• Product Name: Z-GLY-PRO-OSU
• Synonyms: Z-GLY-PRO-OSU;Z-GLYCYL-L-PROLINE HYDROXYSUCCINIMIDE ESTER;Z-GLYCYL-L-PROLINE HYDROXYSUCCINIMIDESTER;Cbz-Gly-Pro-OSu
• CAS NO: 38417-02-6
• Molecular Formula: C₁₉H₂₁N₃O₇
• Molecular Weight: 403.39
• EINECS: 1533716-785-6
• Mol File: 38417-02-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: Z-GLY-PRO-OSU(CAS DataBase Reference)
• NIST Chemistry Reference: Z-GLY-PRO-OSU(38417-02-6)
• EPA Substance Registry System: Z-GLY-PRO-OSU(38417-02-6)

Safety Data

• Hazardous Substances Data: 38417-02-6(Hazardous Substances Data)

Usage

Uses

(Benzyloxycarbonyl)glycyl-L-proline N-Hydroxysuccinimide Ester Trifluoroacetic Acid is useful for the synthesis of glycyl-L-prolyl-L-glutamic acid analogs.

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 1160-54-9 (2S)-1-(2-[[(benzyloxy)carbonyl]amino]acetyl)tetrahydro-1H-pyrrole-2-carboxylic acid 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 66449-90-9 (2S)-N-(N-Benzyloxycarbonylglycyl)proline methyl ester 
• 147-85-3 L-proline 

Downstream Products

• 39622-01-0 Z-Gly-Pro-Gly-OBu^t 
• 840525-19-1 α-benzyl N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-L-glutamate 
• 841233-87-2 benzyl (4S)-N-benzyloxycarbonyl-glycyl-L-prolyl-4-amino-5-hydroxypentanoate 
• 840525-25-9 benzyl (2S)-N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-2-amino-5-hydroxypentanoate 
• 840525-23-7 N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-L-Nγ,Nγ-dimethyl-glutamine α-benzyl ester 
• 840525-21-5 N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-L-Nγ-methyl-glutamine α-benzyl ester 
• 840525-20-4 N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-L-glutamine α-benzyl ester 
• 108562-96-5 Boc-Cys(MBzl)-Gly-Pro-Gly-OBu^t 

Relevant articles and documents

The Study of Stability of Proline-Containing Derivatives of Dopamine and Serotonin in the Biological Media in Vitro Experiments

Abstract—: The peptides Boc-Gly-Pro-DP, Z-Gly-Pro-DP, LA-Gly-Pro-DP, Boc-Gly-Pro-Srt, Z-Gly-Pro-Srt have been synthesized for the first time. The study of their stability in the presence of leucine aminopeptidase, carboxypeptidase Y, carboxypeptidase B, and proline endopeptidase (PEP) has shown that the synthesized peptides are stable in the presence of aminopeptidases and carboxypeptidases. In the presence of PEP, dopamine (DP) and serotonin (Srt) have been cleaved from these substances. Thus, the originally synthesized proline derivatives of Srt and DP may be considered as the resources, from which Srt and DP can be gradually released. This creates the possibility of a prolonged action of these biologically active compounds on cells and, consequently, on the whole body.

Synthesis and neuroprotective activity of analogues of glycyl-L-prolyl-L- glutamic acid (GPE) modified at the α-carboxylic acid

The synthesis of nine GPE* analogues, wherein the α-carboxylic acid group of glutamic acid has been modified, is described by coupling readily accessible N-benzyloxycarbonyl-glycyl-l-proline 2 with various analogues of glutamic acid. Pharmacological evaluation of the novel compounds was undertaken to further understand the role of the glutamate residue on the observed neuroprotective properties of the endogenous tripeptide GPE.