384338-20-9

Basic information

• Product Name: 1-benzyl-4-methylpiperidin-3-ol
• Synonyms: 1-benzyl-4-methylpiperidin-3-ol;4-Methyl-1-(phenylmethyl)-3-piperidinol;3-Piperidinol, 4-Methyl-1-(phenylMethyl)-;Trans-1-benzyl-4-methyl-piperidin-3-ol
• CAS NO: 384338-20-9
• Molecular Formula: C13H19NO
• Molecular Weight: 205.3
• Mol File: 384338-20-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 305.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.064
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.84±0.40(Predicted)
• CAS DataBase Reference: 1-benzyl-4-methylpiperidin-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-methylpiperidin-3-ol(384338-20-9)
• EPA Substance Registry System: 1-benzyl-4-methylpiperidin-3-ol(384338-20-9)

Safety Data

• Hazardous Substances Data: 384338-20-9(Hazardous Substances Data)

Usage

General Description

1-benzyl-4-methylpiperidin-3-ol is a chemical compound with the molecular formula C16H23NO and a molecular weight of 245.36 g/mol. It is a piperidine derivative with a benzyl group attached to the nitrogen atom and a methyl group attached to the fourth carbon of the piperidine ring. 1-benzyl-4-methylpiperidin-3-ol has potential pharmaceutical applications, particularly as an opioid receptor modulator, and has been studied for its analgesic and antipruritic properties. It may also have potential as a treatment for substance use disorders. Additionally, it has been investigated for its use in the synthesis of other organic compounds. However, this compound may have potential psychoactive effects and should be handled and used with caution.

Upstream product

• 32018-56-7 1-benzyl-4-methyl-1 ,2,3,6-tetrahydropyridine 
• 108-89-4 picoline 
• 100-44-7 benzyl chloride 
• 23662-66-0 1-benzyl-4-methylpyridinium chloride 
• 32018-96-5 1-benzyl-4-methyl-piperidin-3-one 
• 6998-30-7 methylamine acetate 
• 100-46-9 benzylamine 
• 41979-39-9 4-piperidone hydrochloride 
• 100-39-0 benzyl bromide 
• 3612-20-2 1-phenylmethyl-4-piperidone 

Downstream Products

• 374822-48-7 C₆H₁₃NO 
• 384338-23-2 (1-benzyl-4-methyl-piperidin-3-yl)-methyl-amine 
• 923036-30-0 N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-(7-p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1354621-59-2 C₁₄H₂₂N₂ 
• 1259404-17-5 tasocitinib 

Relevant articles and documents

Short enantioselective total synthesis of (+)-tofacitinib

An enantioselective total synthesis of Tofacitinib (CP-690,550), a Janus tyrosine kinase (JAK3) specific inhibitor has been achieved from the readily available 4-piperidone. Proline catalysed hydroxylation is the key step for the synthesis of enantiopure 1-benzyl-4-methylpiperidin-3-ol.

Method for preparing lactam compound

The invention relates to a preparation method of a lactam compound, and belongs to the field of medicinal chemistry. The preparation method comprises the following steps: carrying out an asymmetric hydrogenation reaction on raw materials under the action of a ruthenium catalyst and a hydrogen donor reagent, and carrying out a post treatment to obtain the target compound. The product obtained by the method is high in ee value, the method is simple and convenient, and the target compound can be easily, conveniently and efficiently obtained.

Formal asymmetric synthesis of (+)-tofacitinib

Tofacitinib is an efficient and selective Janus kinase 3 (JAK3) inhibitor, and is used as an immunosuppressant drug for the treatment of rheumatoid arthritis and transplant patients. Herein we report a concise formal asymmetric synthesis of tofacitinib from homochiral 1,3-dioxolanone 10b, which was elaborated through a highly stereoselective Michael addition followed by solvent-free removal of the chiral auxiliary and ring cyclization to furnish chiral imide 8. The preparation of tofacitinib's precursor 16 could be obtained after reduction of 8 followed by sequential oxidation, reductive amination and SNAr reactions.