386-71-0

Basic information

• Product Name: 2-nitro-3-(trifluoromethyl)aniline
• Synonyms: 2-nitro-3-(trifluoromethyl)aniline;2-Nitro-3-(trifluoromethyl)benzenamine;2-nitro-3-amino trifluorotolue;(2-Nitro-3-trifluoroMethylphenyl)aMine;2-nitro-3-aMino trifluorotoluene;3-Trifluoromethyl-2-nitroaniline;NSC 10269;3-Amino-2-nitrobenzotrifluoride
• CAS NO: 386-71-0
• Molecular Formula: C₇H₅F₃N₂O₂
• Molecular Weight: 206.12
• Mol File: 386-71-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 64 °C
• Boiling Point: 287.2 °C at 760 mmHg
• Flash Point: 127.5 °C
• Appearance: /
• Density: 1.503 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -1.45±0.10(Predicted)
• CAS DataBase Reference: 2-nitro-3-(trifluoromethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitro-3-(trifluoromethyl)aniline(386-71-0)
• EPA Substance Registry System: 2-nitro-3-(trifluoromethyl)aniline(386-71-0)

Safety Data

• Hazardous Substances Data: 386-71-0(Hazardous Substances Data)

Usage

General Description

2-nitro-3-(trifluoromethyl)aniline is a chemical compound with the molecular formula C7H6F3NO2. It is a pale yellow solid that is commonly used in the synthesis of various pharmaceuticals and agrochemicals. The presence of a nitro group and a trifluoromethyl group in its structure make it a versatile intermediate for the production of a wide range of organic compounds. It is also used as an intermediate in the manufacturing of dyes and other fine chemicals. 2-nitro-3-(trifluoromethyl)aniline is a hazardous chemical and should be handled with care, as it can cause irritation to the skin, eyes, and respiratory system if not properly managed.

Upstream product

• 387-19-9 N-(2-nitro-3-(trifluoromethyl)phenyl)acetamide 
• 384-22-5 2-nitrobenzotrifluoride 
• 351-36-0 N-acetyl-3-trifluoromethylbenzenamine 

Downstream Products

• 384-22-5 2-nitrobenzotrifluoride 
• 520-21-8 1,3-bis-(2-nitro-3-trifluoromethyl-phenyl)-triazene 
• 386-72-1 2-nitro-3-(trifluoromethyl)phenol 
• 313-12-2 2-amino-3-(trifluoromethyl)benzoic acid 
• 360-60-1 3-(trifluoromethyl)benzene-1,2-diamine 
• 571-82-4 8-nitro-7-trifluoromethyl-quinoline 
• 4605-35-0 2-Nitro-3-trifluormethyl-diphenylamin 
• 668-28-0 3-Brom-2-nitro-trifluormethylbenzol 
• 316-98-3 N-(7-trifluoromethyl-[8]quinolyl)-acetamide 
• 389-21-9 toluene-4-sulfonic acid-(7-trifluoromethyl-[8]quinolyl ester) 
• 440-39-1 4-nitro-benzoic acid-(7-trifluoromethyl-[8]quinolyl ester) 
• 392-11-0 4-(trifluoromethyl)-1H-benzo[d]imidazole 
• 389-61-7 5-trifluoromethyl-2,3-diphenylquinoxaline 
• 343-19-1 N,N'-(3-trifluoromethyl-o-phenylene)-bis-acetamide 

Relevant articles and documents

SUBSTITUTED BENZIMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted benzimidazole carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat a medical disorder, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.

DIHYDROOROTATE DEHYDROGENASE INHIBITORS

The invention relates to compounds of formula (I) wherein R1, R2, X1, X2, Y, Ra, Rb, Q have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.

Nitroarylamines via the Vicarious Nucleophilic Substitution of Hydrogen: Amination, Alkylamination, and Arylamination of Nitroarenes with Sulfenamides

A new reaction of sulfenamides with electrophilic arenes under basic conditions is described. The σ adducts formed from nitroarenes and the anions of sulfenamides undergo elimination of thiol to produce the corresponding o- and/or p-nitroanilines. This reaction is analogous to the known alkylation and hydroxylation of nitroarenes via the vicarious nucleophilic substitution of hydrogen (VNS). The reaction gives access to a wide range of substituted nitroanilines, nitronaphthylamines, and aminoheterocycles. By means of the reaction with N-alkyl- and N-arylsulfenamides, it is possible to obtain N-alkylnitroanilines and nitrodiarylamines. By varying the structure of sulfenamide and the reaction conditions, particularly the nature and concentration of the base, it is possible to control the orientation of animation.