38922-74-6

Basic information

• Product Name: 2-(4-CHLORO-PHENYL)-IMIDAZO[1,2-A]PYRIDINE
• Synonyms: BUTTPARK 7\05-92;2-(4-CHLORO-PHENYL)-IMIDAZO[1,2-A]PYRIDINE
• CAS NO: 38922-74-6
• Molecular Formula: C₁₃H₉ClN₂
• Molecular Weight: 228.68
• Mol File: 38922-74-6.mol
• Article Data: 97

Chemical Properties

• Melting Point: 208 °C
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 6.47±0.50(Predicted)
• CAS DataBase Reference: 2-(4-CHLORO-PHENYL)-IMIDAZO[1,2-A]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLORO-PHENYL)-IMIDAZO[1,2-A]PYRIDINE(38922-74-6)
• EPA Substance Registry System: 2-(4-CHLORO-PHENYL)-IMIDAZO[1,2-A]PYRIDINE(38922-74-6)

Safety Data

• Hazardous Substances Data: 38922-74-6(Hazardous Substances Data)

Usage

General Description

2-(4-Chloro-phenyl)-imidazo[1,2-a]pyridine is a chemical compound with the molecular formula C12H8ClN3. It is a heterocyclic compound with an imidazo-pyridine structure, which makes it useful in pharmaceutical research as a potential drug candidate. The presence of the chloro-phenyl group suggests that it may have biological activity, potentially making it useful in the development of new drugs. 2-(4-CHLORO-PHENYL)-IMIDAZO[1,2-A]PYRIDINE may have diverse applications as it can be involved in the synthesis of various pharmaceuticals and agrochemicals. Furthermore, it has the potential to be used as a building block in organic chemistry for the preparation of more complex molecules.

Upstream product

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• 54187-96-1 1-(chloromethyl)-1H-benzotriazole 
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Downstream Products

• 131947-29-0 2-(4-chlorophenyl)-3-chloroimidazo<1,2-a>pyridine 
• 349482-09-3 2-chloro-1-[2-(4-chloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-2,2-difluoro-ethanone 
• 305832-50-2 2-(4'-chlorophenyl)-3-nitrosoimidazo[1,2-a]pyridine 
• 338415-39-7 1-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine 
• 82622-54-6 2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylacetamide 
• 17744-99-9 2-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acetonitrile 
• 21801-83-2 2-[2-(4-chloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide 
• 17745-06-1 [2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]acetic acid 
• 158958-76-0 3-bromo-2-(4'-chlorophenyl)imidazo[1,2-a]pyridine 
• 1310492-82-0 2-(4-chlorophenyl)-3-(phenylthio)-imidazo[1,2-a]pyridine 
• 1360127-61-2 N-((2-(4-chlorophenyl)-imidazo[1,2-a]pyridin-3-yl)(3-nitrophenyl)methyl)acetamide 
• 1357622-10-6 (2E)-3-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-1-(4-methylsulfonylphenyl)prop-2-en-1-one 
• 1357622-11-7 (2E)-3-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-1-(3-fluorophenyl)prop-2-en-1-one 
• 1357622-12-8 (2E)-3-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-1-(3-nitrophenyl)prop-2-en-1-one 

Relevant articles and documents

Oxidation Potential-Guided Electrochemical Radical-Radical Cross-Coupling Approaches to 3-Sulfonylated Imidazopyridines and Indolizines

Oxidation potential-guided electrochemical radical-radical cross-coupling reactions between N-heteroarenes and sodium sulfinates have been established. Thus, simple cyclic voltammetry measurement of substrates predicts the likelihood of successful radical-radical coupling reactions, allowing the simple and direct synthetic access to 3-sulfonylated imidazopyridines and indolizines. The developed electrochemical radical-radical cross-coupling reactions to sulfonylated N-heteroarenes boast the green synthetic nature of the reactions that are oxidant- and metal-free.

Design, synthesis and anticancer activity of sulfenylated imidazo-fused heterocycles

We report herein, the design, synthesis and study of anticancer properties of sulfenylated 2-phenylimidazo[1,2-a]pyridines and their analogues. A set of twenty sulfenylated imidazo[1, 2-a]pyridine derivatives were synthesized. Whereby elusive amendments to the imidazo[1,2-a]pyridine motif confer dramatic changes in functional affinity of a novel action to modulate anticancer activity in seven different human cancer cell lines i.e.: MDA MB 231 (breast), HepG2 (liver), Hela (cervical), A549 (lung), U87MG (glioblastoma), SKMEL-28 (skin melanoma) and DU-145 (prostate) by employing MTT assay. Among the series, compounds 4e (naphthalene), 4f (styrene) and 4h (thiomethyl) showed potent activity towards human liver cancer cells HepG2. Cell cycle analysis results revealed that these compounds arrested the cell cycle at G2/M phase and induced apoptosis in human liver cancer cells HepG2. It was further confirmed by Hoechst staining, Measurement of mitochondrial membrane potential (ΔΨm) and Annexin V-FITC assay.

SUBSTITUTED DIAZAHETERO-BICYCLIC COMPOUNDS AND THEIR USE

The present application relates to novel (imidazo[1,2-a]pyridin-3-yl)methyl-substituted diazaheterobicyclic compounds, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to th