3894-09-5 Usage
Description
CYCLOHEXYLPHENYLACETIC ACID, also known as α-Cyclohexyl-benzeneacetic Acid, is a grey crystalline powder with unique chemical properties. It serves as a valuable synthetic intermediate in the pharmaceutical industry due to its versatile reactivity and structural characteristics.
Uses
Used in Pharmaceutical Industry:
CYCLOHEXYLPHENYLACETIC ACID is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its application is primarily due to its ability to react with other molecules to form new compounds with potential therapeutic properties.
1. Cholecystokinin-B Receptor Antagonists:
CYCLOHEXYLPHENYLACETIC ACID is used as a reactant to prepare phenylureidobenzazepinones, which are cholecystokinin-B receptor antagonists. These antagonists have potential applications in treating conditions related to gastrointestinal motility and secretion, such as irritable bowel syndrome and pancreatitis.
2. AMP-Activated Protein Kinase Activators:
CYCLOHEXYLPHENYLACETIC ACID can also be used to synthesize benzimidazole derivatives, which are potent AMP-activated protein kinase (AMPK) activators. AMPK activators play a crucial role in regulating cellular energy homeostasis and have potential applications in treating metabolic disorders, such as obesity and type 2 diabetes.
Check Digit Verification of cas no
The CAS Registry Mumber 3894-09-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,9 and 4 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 3894-09:
(6*3)+(5*8)+(4*9)+(3*4)+(2*0)+(1*9)=115
115 % 10 = 5
So 3894-09-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H18O2/c15-14(16)13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1,3-4,7-8,12-13H,2,5-6,9-10H2,(H,15,16)/p-1/t13-/m1/s1
3894-09-5Relevant articles and documents
Oxidative cleavage of α-aryl aldehydes using iodosylbenzene
Havare, Nizam,Plattner, Dietmar A.
, p. 5078 - 5081,4 (2020/09/15)
We found that α-aryl aldehydes can be cleaved to chain-shortened carbonyl compounds and formaldehyde by various iodosylbenzene complexes. A mechanistic scheme is presented that accounts for the loss of one carbon atom. Formaldehyde is further oxidized to CO and CO2 under the reaction conditions.
Discovery of new C3aR ligands. Part 2: Amino-piperidine derivatives
Denonne, Frederic,Binet, Sophie,Burton, Maggi,Collart, Philippe,Defays, Sabine,Dipesa, Alan,Eckert, Maria,Giannaras, Alexander,Kumar, Seema,Levine, Beth,Nicolas, Jean-Marie,Pasau, Patrick,Pegurier, Cecile,Preda, Dorin,Van houtvin, Nathalie,Volosov, Andrew,Zou, Dong
, p. 3262 - 3265 (2008/02/08)
The synthesis and structure-activity relationships against the C3a receptor of a series of substituted aminopiperidine derivatives are reported. DMPK properties and functional activities of selected compounds are described. The compounds obtained are the first non-arginine ligands of C3aR.
Oxidative decarboxylation of arylacetic acids mediated by peroxysulfur intermediate generated from 2-nitrobenzenesulfonyl chloride and superoxide
Kim II, Yong,Kim, Yong Hae
, p. 639 - 642 (2007/10/03)
The oxidative decarboxylation of aryl, α, α-diaryl, or arylalkylacetic acids has been achieved by a 2-nitrobenzenesulfonyl peroxy radical intermediate (I) generated by the reaction of 2-nitrobenzenesulfonyl chloride with potassium superoxide at -20°C in dry acetonitrile.