39166-25-1

Basic information

• Product Name: Morpholine, 4-[(1E)-2-phenylethenyl]-
• CAS NO: 39166-25-1
• Molecular Formula: C12H15NO
• Molecular Weight: 189.257
• Mol File: 39166-25-1.mol
• Article Data: 35

Chemical Properties

• CAS DataBase Reference: Morpholine, 4-[(1E)-2-phenylethenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine, 4-[(1E)-2-phenylethenyl]-(39166-25-1)
• EPA Substance Registry System: Morpholine, 4-[(1E)-2-phenylethenyl]-(39166-25-1)

Safety Data

• Hazardous Substances Data: 39166-25-1(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 100-42-5 styrene 
• 17123-83-0 N-(phenylacetyl)morpholine 
• 82489-29-0 (E)-N,N-diethyl-2-phenylethen-1-amine 
• 55606-20-7 (E)-N-styrylpiperidine 
• 122-78-1 phenylacetaldehyde 
• 103-80-0 phenylacetyl chloride 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 36681-72-8 4-(2,2,2-trichloro-ethyl)-morpholine 
• 100-52-7 benzaldehyde 
• 20684-76-8 4-<(Diphenylphosphinoyl)methyl>morpholine 
• 536-74-3 phenylacetylene 
• 588-72-7 [(E)-2-bromoethenyl]benzene 
• 1566-67-2 (Z)-styryl acetate 

Downstream Products

• 78950-74-0 2-morpholinoisoflav-3-ene 
• 84395-76-6 (E)-N-benzyl-N-methyl-2-phenylethen-1-amine 
• 6908-73-2 (E)-1-styrylpyrrolidine 
• 55606-20-7 (E)-N-styrylpiperidine 
• 82489-29-0 (E)-N,N-diethyl-2-phenylethen-1-amine 

Relevant articles and documents

Regio- and Enantioselective Formal Hydroamination of Enamines for the Synthesis of 1,2-Diamines

The asymmetric formal hydroamination of enamines using a CuH catalyst is reported. The method provides a straightforward and efficient approach to the synthesis of chiral 1,2-dialkyl amines in good yields with high levels of enantioselectivities for a broad range of substrates, and should have significant value for the preparation of molecules bearing a 1,2-diamine motif.

An Efficient One–pot Procedure for the Direct Preparation of 4,5-Dihydroisoxazoles from Amides

A Mo(CO)6 (molybdenumhexacarbonyl) catalyzed reductive functionalization of amides to afford 5-amino substituted 4,5-dihydroisoxazoles is presented. The reduction of amides generates reactive enamines, which upon the addition of hydroximinoyl chlorides and base undergoes a 1,3-dipolar cycloaddition reaction that gives access to the desired heterocyclic compounds. The transformation of amides is highly chemoselective and tolerates functional groups such as nitro, nitriles, esters, and ketones. Furthermore, a versatile scope of 4,5-dihydroisoxazoles derived from a variety of hydroximinoyl chlorides and amides is demonstrated. (Figure presented.).

Dynamic Covalent Chemistry of Aldehyde Enamines: BiIII- and ScIII-Catalysis of Amine–Enamine Exchange

The dynamic exchange of enamines from secondary amines and enolizable aldehydes has been demonstrated in organic solvents. The enamine exchange with amines was efficiently catalyzed by Bi(OTf)3 and Sc(OTf)3 (2 mol %) and the equilibria (60 mm) could be attained within hours at room temperature. The formed dynamic covalent systems displayed high stabilities in basic environment with 2 % by-product formation within one week after complete equilibration. This study expands the scope of dynamic C?N bonds from imine chemistry to enamines, enabling further dynamic methodologies in exploration of this important class of structures in systems chemistry.