392691-83-7Relevant articles and documents
Human β3 adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides
Naylor, Elizabeth M.,Parmee, Emma R.,Colandrea, Vincent J.,Perkins, Leroy,Brockunier, Linda,Candelore, Mari R.,Cascieri, Margaret A.,Colwell Jr., Lawrence F.,Deng, Liping,Feeney, William P.,Forrest, Michael J.,Hom, Gary J.,MacIntyre, D. Euan,Strader, Catherine D.,Tota, Laurie,Wang, Pei-Ran,Wyvratt, Matthew J.,Fisher, Michael H.,Weber, Ann E.
, p. 755 - 758 (1999)
The cyclopentylpropylimidazolidinone L-766,892 is a potent β3 AR agonist (EC50 5.7 nM, 64% activation) with 420- and 130-fold selectivity over binding to the β1 and β2 ARs, respectively. In anesthetized rhesus monkeys, L-766,892 elicited dose-dependent hyperglycerolemia (ED50 0.1 mg/kg) with minimal effects on heart rate.
SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS
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Page/Page column 28; 107, (2011/09/19)
Compounds of formula (I): wherein R1, R2, R3, R4, R7, R6, R7, R8, R9, A, X and Y as defined herein are provided as useful for the treatment of cancer or for
