393-23-7

Basic information

• Product Name: N-(4-chloro-2-trifluoromethl-pheny)-Acetamide
• Synonyms: N-(4-chloro-2-trifluoromethl-pheny)-Acetamide;4-Fluoro-2-(trifluoroMethyl)acetanilide;N-(4-Fluoro-2-(trifluoromethyl)phenyl)acetamide
• CAS NO: 393-23-7
• Molecular Formula: C₉H₇F₄NO
• Molecular Weight: 221.1515928
• Mol File: 393-23-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-chloro-2-trifluoromethl-pheny)-Acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chloro-2-trifluoromethl-pheny)-Acetamide(393-23-7)
• EPA Substance Registry System: N-(4-chloro-2-trifluoromethl-pheny)-Acetamide(393-23-7)

Safety Data

• Hazardous Substances Data: 393-23-7(Hazardous Substances Data)

Usage

General Description

N-(4-chloro-2-trifluoromethyl-phenyl)-acetamide is a chemical compound with the molecular formula C9H8ClF3NO. It is a white crystalline solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. N-(4-chloro-2-trifluoromethl-pheny)-Acetamide is known for its anti-inflammatory and analgesic properties, making it a valuable component in the development of pain-relieving medications. N-(4-chloro-2-trifluoromethyl-phenyl)-acetamide is also used in the production of various industrial products, including dyes, pigments, and polymers. Its chemical properties and potential applications make it a significant compound in the field of organic chemistry and drug discovery.

Upstream product

• 393-39-5 4-fluoro-2-(trifluoromethyl)aniline 
• 108-24-7 acetic anhydride 
• 401-80-9 3-fluoro-trifluoromethylbenzene 
• 393-09-9 4-fluoro-1-nitro-2-trifluoromethyl-benzene 
• 351-83-7 4'-fluoroacetanilide 
• 2926-29-6 Langlois reagent 

Downstream Products

• 389-75-3 acetic acid-(4-fluoro-2-nitro-6-trifluoromethyl-anilide) 
• 346-14-5 (4-fluoro-phenyl)-(4-fluoro-2-trifluoromethyl-phenyl)-amine 
• 344-29-6 4-fluoro-2-nitro-6-trifluoromethyl-aniline 
• 1231750-42-7 N-(4-methoxy-2-nitro-6-trifluoromethyl-phenyl)-acetamide 
• 15804-19-0 quinoxaline-2,3-dione 
• 393-39-5 4-fluoro-2-(trifluoromethyl)aniline 

Relevant articles and documents

4 - Fluorine substituted aryl amine compound and synthesis method thereof

The invention discloses a synthesis method of 4 -fluorine substituted aryl amine compound, which comprises the following steps: 1) taking acyl-protected phenylhydroxylamine as a substrate, and generating 4 -fluorine substituted aniline compound under basic conditions by taking sulfonyl fluoride as a fluorine source in a polar solvent. 2) The deprotection is carried out under dilute acid conditions or Pd by catalytic hydrogenation to give the 4 - fluorine-substituted aryl amine compound. 4 - Fluorine substituted aniline compounds which are synthesized by the invention greatly increase the lipophilic property due to the introduction of fluorine atoms, and can be widely applied to preparation of fluorine-containing drugs and pesticide and dye intermediates. , The adopted raw materials are industrial products, are cheap and easily available, and are commercially available. 4 - Fluoroaryl aniline prepared by the method is high in yield, and the product with the purity 90% can be obtained in a yield of more than ≥ 99%. The method is simple to operate and low in cost, is very suitable for industrialization, and can be widely popularized and used.

Preparation 2-trifluoromethyl-4-substituted aniline compounds

The invention relates to a method for preparing 2-trifluoromethyl-4-substituted phenylamine and 2-trifluoromethyl-4-substituted acetanilide. The method for preparing the2-trifluoromethyl-4-substituted phenylamine and 2-trifluoromethyl-4-substituted acetanilide comprises the following main step: in the presence of sodium trifluoromethanesulfonate and tert-butyl hydroperoxide but no metal salt catalyst and under the stirring condition, maintaining a 4-substituted phenylamine compound (concrete structure shown in a formula II is described in the specification) in a reaction medium of mixture composed of dichloromethane and water at the temperature of 0-25 DEG C for 72-120 hours, so that the 2-trifluoromethyl-4-substituted phenylamine target product is obtained. The preparation method provided by the invention has potential commercial value.

Palladium-catalyzed trifluoromethylation of aromatic C-H bond directed by an acetamino group

The first palladium-catalyzed ortho-trifluoromethylation of the aromatic C-H bond directed by an acetamino group is reported. This method provides an efficient and green approach to synthesize the highly biological potential key structure of ortho-CF3 acetanilides and anilines.