39560-34-4

Basic information

• Product Name: 3-(2-hydroxybenzoyl)propionic acid
• Synonyms: 3-(2-hydroxybenzoyl)propionic acid;2-Hydroxy-γ-oxobenzenebutanoic acid;3-(2-HYDROXYBENZOYL)PROPIONIC ACID(WXG01892);4-(2-Hydroxy-phenyl)-4-oxo-butyric acid
• CAS NO: 39560-34-4
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.184
• EINECS: 254-508-4
• Mol File: 39560-34-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 393.8°Cat760mmHg
• Flash Point: 206.1°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 6.6E-07mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 3-(2-hydroxybenzoyl)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-hydroxybenzoyl)propionic acid(39560-34-4)
• EPA Substance Registry System: 3-(2-hydroxybenzoyl)propionic acid(39560-34-4)

Safety Data

• Hazardous Substances Data: 39560-34-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10O4/c11-8-4-2-1-3-7(8)9(12)5-6-10(13)14/h1-4,11H,5-6H2,(H,13,14)

Upstream product

• 108-30-5 succinic acid anhydride 
• 108-95-2 phenol 
• 6311-68-8 monophenyl succinate 
• 15571-99-0 4-Chlorophenyl Hydrogen Succinate 
• 56871-93-3 methyl 3-(2-hydroxybenzoyl)-propionate 
• 7446-70-0 aluminium trichloride 
• 108-88-3 toluene 

Downstream Products

• 35387-19-0 2-hydroxybenzenebutanoic acid 
• 39496-84-9 4-(2-hydroxy-phenyl)-4-oxo-butyric acid ethyl ester 
• 39595-35-2 4-(2-ethoxy-phenyl)-4-oxo-butyric acid 
• 103987-16-2 β-methoxy-γ-oxo-γ-phenylbutanoic acid 
• 75349-02-9 cholesteryl 3-(o-hydroxybenzoyl)propionate 
• 133414-47-8 10,10a-Dihydro-1H,3H-9-oxa-3,4-diaza-phenanthren-2-one 
• 102172-07-6 5-(2-ethoxy-phenyl)-5-(2-methoxy-phenyl)-dihydro-furan-2-one 
• 115386-92-0 1-(2-ethoxy-phenyl)-1,4,4-tris-(2-methoxy-phenyl)-buta-1,3-diene 
• 99046-13-6 4-oxo-4-(2-methoxyphenyl)butyric acid methyl ester 
• 103897-42-3 ethyl 4-(2-methoxyphenyl)-4-oxobutanoate 
• 39606-16-1 3-(o-Propoxybenzoyl)propionic acid 
• 56871-93-3 methyl 3-(2-hydroxybenzoyl)-propionate 
• 39499-60-0 6-(2-hydroxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one 

Relevant articles and documents

Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors

The involvement of μ-calpain in neurological disorders, such as stroke and Alzheimer's disease has attracted considerable interest in the use of calpain inhibitors as therapeutic agents. 4-Aryl-4-oxobutanoic acid amide derivatives 4 were designed as acyclic variants of μ-calpain inhibitory chromone and quinolinone derivatives. Of the compounds synthesized, 4c-2, which possesses a 2-methoxymethoxy group at the phenyl ring and a primary amide at the warhead region most potently inhibited μ-calpain (IC50 = 0.34 μM). Our findings suggest that the 4-aryl-4-oxobutanoic acid amide derivatives should be considered as a new family of μ-calpain inhibitors.