39564-86-8

Basic information

• Product Name: 2-BROMO-4-(4-CHLORO-PHENYL)-THIAZOLE
• Synonyms: 2-BROMO-4-(4-CHLORO-PHENYL)-THIAZOLE;2-bromo-4-(4-chlorophenyl)-1,3-thiazole
• CAS NO: 39564-86-8
• Molecular Formula: C₉H₅BrClNS
• Molecular Weight: 274.5647
• Mol File: 39564-86-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 358.315°C at 760 mmHg
• Flash Point: 170.503°C
• Appearance: /
• Density: 1.658g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.643
• CAS DataBase Reference: 2-BROMO-4-(4-CHLORO-PHENYL)-THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-(4-CHLORO-PHENYL)-THIAZOLE(39564-86-8)
• EPA Substance Registry System: 2-BROMO-4-(4-CHLORO-PHENYL)-THIAZOLE(39564-86-8)

Safety Data

• Hazardous Substances Data: 39564-86-8(Hazardous Substances Data)

Usage

Description

2-Bromo-4-(4-chloro-phenyl)-thiazole, a chemical compound with the molecular formula C9H6BrClNS, is a thiazole derivative featuring a bromine atom and a 4-chloro-phenyl group attached to the thiazole ring. This versatile chemical serves as a valuable building block for the synthesis of more complex organic compounds, particularly in the pharmaceutical and agricultural industries.

Uses

Used in Pharmaceutical Industry:
2-Bromo-4-(4-chloro-phenyl)-thiazole is used as a key intermediate in the synthesis of pharmaceuticals for its potential applications in the development of new drugs. It is particularly considered for the creation of antibiotics or antifungal agents due to its unique molecular structure and functional groups.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Bromo-4-(4-chloro-phenyl)-thiazole is utilized as a component in the synthesis of agrochemicals, contributing to the development of effective products for agricultural applications.
Overall, 2-Bromo-4-(4-chloro-phenyl)-thiazole's presence of both bromine and chlorine atoms enhances its reactivity and makes it a useful precursor for the synthesis of a wide range of organic compounds, solidifying its importance in both the pharmaceutical and agrochemical industries.

InChI:InChI=1/C9H5BrClNS/c10-9-12-8(5-13-9)6-1-3-7(11)4-2-6/h1-5H

Upstream product

• 19339-59-4 1-(4-chloro-phenyl)-2-thiocyanato-ethanone 
• 99-91-2 para-chloroacetophenone 
• 536-38-9 4-chlorobenzoylmethyl bromide 

Downstream Products

• 39564-88-0 3-(4-chloro-phenyl)-pyrido[3,2-d]thiazolo[3,2-a]pyrimidin-5-one 
• 435271-33-3 4-(4-chlorophenyl)-[2-(4-chloropyridin-3-yl)]-1,3-thiazole 
• 1258795-52-6 1-(4-(4-chlorophenyl)thiazol-2-yl)-4-(thiophen-2-yl)-1H-1,2,3-triazole 
• 1258795-51-5 3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-1H-1,2,3-triazol-4-yl)pyridine 
• 1258795-50-4 2-(1-(4-(4-chlorophenyl)thiazol-2-yl)-1H-1,2,3-triazol-4-yl)pyridine 
• 1258795-49-1 1-(4-(4-chlorophenyl)thiazol-2-yl)-4-phenyl-1H-1,2,3-triazole 

Relevant articles and documents

MUTANT IDH1 INHIBITORS USEFUL FOR TREATING CANCER

Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X1, X2, R1-4 and R13-18 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving mutant IDH1 enzymes. Pharmaceutical compositions containing compounds of Formula I or Formula II and methods of treatment comprising administering compounds of Formula I and Formula II are also disclosed.

SUBSTITUTED THIAZOLE DERIVATIVES BEARING 3-PYRIDYL GROUPS, PROCESS FOR PREPARING THE SAME AND USE THEREOF

The present invention provides a pharmaceutical composition having a steroid C17,20-lyase inhibitory activity, which is useful as a prophylactic or therapeutic agent of prostatism, tumor such as breast cancer and the like, more particularly, a steroid C17,20-lyase inhibitor containing a compound represented by the formula: wherein A1 is an aromatic hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, one of A2 and A3 is a hydrogen atom, a halogen atom, a C1-4 aliphatic hydrocarbon group optionally having substituents or an optionally esterified carboxyl group, the other of A2 and A3 is an aromatic hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, and at least one of A1, A2 and A3 is a 3-pyridyl group optionally having substituents, or a salt thereof or a prodrug thereof.