39631-37-3

Basic information

• Product Name: 3H-1,2,4-Triazole-3-thione, 1,2-dihydro-5-(2-methoxyphenyl)-
• Synonyms: 3-(o-methoxyphenyl)-5-mercapto-4H-1,2,4-triazole;3-(o-methoxyphenyl)-5-mercapto-1,2,4-triazole;5-(2-methoxyphenyl)-4H-1,2,4-triazole-3-thiol;3-(o-methoxyphenyl)-5-mercapto-s-triazole;5-(2-methoxy-phenyl)-1,2-dihydro-[1,2,4]triazole-3-thione;3H-1,2,4-Triazole-3-thione,1,2-dihydro-5-(2-methoxyphenyl)
• CAS NO: 39631-37-3
• Molecular Formula: C9H9N3OS
• Molecular Weight: 207.256
• Mol File: 39631-37-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 230 °C(Solv: ethanol (64-17-5))
• Boiling Point: 319.2±44.0 °C(Predicted)
• Density: 1.39±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 3H-1,2,4-Triazole-3-thione, 1,2-dihydro-5-(2-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-1,2,4-Triazole-3-thione, 1,2-dihydro-5-(2-methoxyphenyl)-(39631-37-3)
• EPA Substance Registry System: 3H-1,2,4-Triazole-3-thione, 1,2-dihydro-5-(2-methoxyphenyl)-(39631-37-3)

Safety Data

• Hazardous Substances Data: 39631-37-3(Hazardous Substances Data)

Upstream product

• 21615-34-9 2-Methoxybenzoyl chloride 
• 579-75-9 2-Methoxybenzoic acid 
• 606-45-1 2-methoxybenzoic acid methyl ester 
• 2290-65-5 trimethylsilyl isothiocyanate 
• 7466-54-8 2-methoxybenzoylhydrazine 
• 1448538-32-6 4-benzyl-3-(2-methoxyphenyl)-5-(phenylsulfanyl)-4H-1,2,4-triazole 
• 7653-42-1 N¹-(o-methoxybenzoyl)-3-thiosemicarbazide 

Downstream Products

• 1276032-75-7 5-o-methoxyphenyl-3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylthio)-1,2,4-triazole 
• 1276032-85-9 5-o-methoxyphenyl-3-(β-D-glucopyranosylthio)-1,2,4-triazole 
• 114361-95-4 5-(p-bromophenacylthio)-3-o-methoxyphenyl-s-triazole 
• 114361-96-5 5-(-p-chlorophenacylthio)-3-o-methoxyphenyl-s-triazole 
• 114361-97-6 5-(p-nitrophenacylthio)-3-o-methoxyphenyl-s-triazole 
• 114362-03-7 2-(o-methoxyphenyl)-5-(p-nitrophenyl)thiazolo-<3,2-b>-s-triazole 
• 114362-01-5 2-(o-methoxyphenyl)-5-(p-bromophenyl)thiazolo<3,2-b>-s-triazole 
• 114362-02-6 2-(o-methoxyphenyl)-5-(p-chlorophenyl)thiazolo-<3,2-b>-s-triazole 

Relevant articles and documents

POLYCYCLIC AMIDES AS UBE2K MODULATORS FOR TREATING CANCER

Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating conditions associated with modulation of UBE2K.

Metal beta-lactamase inhibitor

The invention discloses application of a triazole compound, or a stereoisomer thereof, or a salt thereof, or a solvate thereof, represented by formula I in preparation of a metal beta-lactamase inhibitor drug, and belongs to the field of medicinal chemistry. The invention further discloses a preparation method of compounds, and a pharmaceutical composition comprising the compounds.

Synthesis of 5-substituted 3-mercapto-1,2,4-triazoles via Suzuki-Miyaura reaction

3-Bromo- and 3-iodo-N,S-dibenzyl-5-mercapto-1,2,4-triazoles were prepared and demonstrated as versatile building blocks for Suzuki-Miyaura cross-coupling with aryl, heteroaryl, and vinyl boronic acid derivatives. Deprotection of the resulting coupling products provided 5-substituted-3-mercapto-1,2,4-triazoles in good overall yields. This represents a novel and convenient approach for the introduction of a 3-mercapto-1,2,4-triazole substructure into target compounds.