7653-42-1

Basic information

• Product Name: Benzoic acid, 2-methoxy-, 2-(aminothioxomethyl)hydrazide
• CAS NO: 7653-42-1
• Molecular Formula: C9H11N3O2S
• Molecular Weight: 225.271
• Mol File: 7653-42-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-methoxy-, 2-(aminothioxomethyl)hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-methoxy-, 2-(aminothioxomethyl)hydrazide(7653-42-1)
• EPA Substance Registry System: Benzoic acid, 2-methoxy-, 2-(aminothioxomethyl)hydrazide(7653-42-1)

Safety Data

• Hazardous Substances Data: 7653-42-1(Hazardous Substances Data)

Upstream product

• 606-45-1 2-methoxybenzoic acid methyl ester 
• 1147550-11-5 ammonium thiocyanate 
• 2290-65-5 trimethylsilyl isothiocyanate 
• 7466-54-8 2-methoxybenzoylhydrazine 
• 333-20-0 potassium thioacyanate 
• 579-75-9 2-Methoxybenzoic acid 
• 79-19-6 thiosemicarbazide 
• 21615-34-9 2-Methoxybenzoyl chloride 

Downstream Products

• 114362-08-2 2-(o-methoxybenzoylhydrazino)-4-(p-bromophenyl)-thiazole 
• 39631-37-3 3-(o-methoxyphenyl)-5-mercapto-4H-1,2,4-triazole 
• 114362-02-6 2-(o-methoxyphenyl)-5-(p-chlorophenyl)thiazolo-<3,2-b>-s-triazole 
• 114362-01-5 2-(o-methoxyphenyl)-5-(p-bromophenyl)thiazolo<3,2-b>-s-triazole 
• 114362-10-6 3-(o-methoxyphenyl)-5-(p-bromophenyl)thiazolo<2,3-c>-s-triazole 
• 114361-96-5 5-(-p-chlorophenacylthio)-3-o-methoxyphenyl-s-triazole 
• 114361-95-4 5-(p-bromophenacylthio)-3-o-methoxyphenyl-s-triazole 
• 114362-03-7 2-(o-methoxyphenyl)-5-(p-nitrophenyl)thiazolo-<3,2-b>-s-triazole 
• 114361-97-6 5-(p-nitrophenacylthio)-3-o-methoxyphenyl-s-triazole 
• 1276032-75-7 5-o-methoxyphenyl-3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylthio)-1,2,4-triazole 
• 1276032-85-9 5-o-methoxyphenyl-3-(β-D-glucopyranosylthio)-1,2,4-triazole 
• 5711-59-1 2-amino-5-(2-methoxyphenyl)-1,3,4-oxadiazole 

Relevant articles and documents

Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction

Defective in cullin neddylation 1(DCN1) is a co-E3 ligase that is important for cullin neddylation. Dysregulation of DCN1 highly correlates with the development of various cancers. Herein, from the initial high-throughput screening, a novel hit compound 5a containing a phenyltriazole thiol core (IC50 value of 0.95 μM for DCN1-UBC12 interaction) was discovered. Further structure-based optimization leads to the development of SK-464 (IC50 value of 26 nM). We found that SK-464 not only directly bound to DCN1 in vitro, but also engaged cellular DCN1, suppressed the neddylation of cullin3, and hindered the migration and invasion of two DCN1-overexpressed squamous carcinoma cell lines (KYSE70 and H2170). These findings indicate that SK-464 may be a novel lead compound targeting DCN1-UBC12 interaction.

Trimethylsilyl isothiocyanate (TMSNCS): An efficient reagent for the one-pot synthesis of mercapto-1,2,4-triazoles

A mild, convenient, and efficient one-pot synthesis of mercapto-1,2,4- triazoles is described. Various hydrazides efficiently reacted with trimethylsilyl isothiocyanate (TMSNCS) under basic condition to give mercapto-1,2,4-triazoles in high yields.

GLUCOKINASE ACTIVATORS

Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.