3982-91-0 Usage
Description
Thiophosphoryl chloride, also known as thiophosphoryl dichloride, is a colorless to slightly yellowish liquid with a fuming appearance. It has a boiling point of 257°F (125°C) and is known to be corrosive to metals and tissue. It also has the potential to irritate the eyes and mucous membranes.
Uses
Used in Chemical Synthesis:
Thiophosphoryl chloride is used as a reagent in the chemical synthesis process for creating various compounds. Its application is particularly notable in the synthesis of O-ethyl dichlorothiophosphate, which is an important intermediate in the production of certain pesticides and other chemical products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, thiophosphoryl chloride is utilized as a key intermediate in the synthesis of various pharmaceutical compounds. Its ability to react with a wide range of substrates makes it a versatile tool in the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
Thiophosphoryl chloride is also employed in the agrochemical industry for the production of pesticides and other crop protection agents. Its role in the synthesis of O-ethyl dichlorothiophosphate and other related compounds contributes to the development of effective and targeted pest control solutions.
Used in Research and Development:
Due to its unique chemical properties and reactivity, thiophosphoryl chloride is often used in research and development settings to explore new chemical reactions and synthesize novel compounds. This application helps advance the understanding of chemical processes and contributes to the discovery of new materials and products across various industries.
Air & Water Reactions
Fumes in air. Decomposes in water to form phosphoric acid and hydrochloric acid (hydrogen chloride). Both substances are corrosive to metal or tissue. Can also form hydrogen sulfide (H2S), a toxic flammable gas, in reaction with water [AAR 1991].
Reactivity Profile
THIOPHOSPHORYL CHLORIDE is acidic. Incompatible with bases (including amines), with strong oxidizing agents, and with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Hazard
Strong irritant to skin and tissue.
Health Hazard
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Vapors may accumulate in confined areas (basement, tanks, hopper/tank cars etc.). Substance will react with water (some violently), releasing corrosive and/or toxic gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Safety Profile
Poison by inhalation.
Moderately toxic by ingestion. A corrosive
irritant to skin, eyes, and mucous
membranes. Explosive reaction with
methylmagnesium iodlde. Explosive
reaction with pentaerythritol + heat. Reacts
with water or steam to produce toxic and
corrosive fumes. When heated to
decomposition it emits highly toxic fumes of
POx, SOx, and Cl-.
Purification Methods
Possible impurities are PCl5, H3PO4, HCl and AlCl3. Gently mix it with H2O to avoid a heavy emulsion; the product decoulorises immediately and settles to the bottom layer. It is soluble in *C6H6 and CCl4. [Duval Inorg Synth IV 73 1953.] HARMFUL VAPOURS.
Check Digit Verification of cas no
The CAS Registry Mumber 3982-91-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,9,8 and 2 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 3982-91:
(6*3)+(5*9)+(4*8)+(3*2)+(2*9)+(1*1)=120
120 % 10 = 0
So 3982-91-0 is a valid CAS Registry Number.
InChI:InChI=1/Cl3PS/c1-4(2,3)5
3982-91-0Relevant articles and documents
Woodstock, W. H.,Adler, H.
, p. 464 - 467 (1932)
PROCESS FOR PREPARATION OF O, O-DIMEHYL PHOSPHORAMIDOTHIOATE AND N-(METHOXY-METHYLSULFANYLPHOSPHORYL) ACETAMIDE
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Paragraph 0028-0029, (2020/02/08)
Preparation of O,O-dimethyl phosphoramidothioate and O,O-dimethyl phosphoroamidothioate. A process of making O,O-dimethyl phosphoroamidothioate is described including reacting sulfur with PCl3 to form PSCl3, reacting the PSCl3 formed with methanol to form O-methyl phosphorodichloridothioate, and reacting the O-methyl phosphorodichloridothioate formed with methyl lye to form O,O-dimethyl phosphorochloridothioate in solution in CH2Cl2, and reacting the O,O-dimethyl phosphorochloridothioate formed with sodium hydroxide and ammonium hydroxide to form O,O-dimethyl phosphoroamidothioate in solution in CH2Cl2. Reacting the O,O-dimethyl phosphoroamidothioate formed with catalytic dimethyl sulfate to form methamidophos, and reacting the methamidophos formed with acetic anhydride to form N-(methoxy-methylsulfanylphosphoryl) acetamide is also described. Throughout the process, the O,O-dimethyl phosphorochloridothioate and the O,O-dimethyl phosphoroamidothioate formed are maintained in solution in CH2Cl2 at all times.
Photochemistry of Low-Temperature Matrices Containing Carbonyl Sulfide: Reactions of Sulfur Atoms with the Phosphorus Trihalides PF3 and PCl3 and the Hydrocarbons CH4, C2H4, and C2H2
Hawkins, Michael,Almond, Matthew,Downs, Anthony J.
, p. 3326 - 3334 (2007/10/02)
Exposure of a solid argon matrix containing the molecules OCS and PX3 (X = F or Cl) at ca. 20 K to broad-band ultraviolet radiation leads to the formation of CO and the corresponding thiophosphorus(V) halides SPX3, as witnessed by the infrared spectrum of the matrix.Photolysis of a solid methane matrix containing OCS at 13-20 K on exposure to radiation with wavelengths near 230 nm gives rise to CO, methanethiol, CH3SH, thioformaldehyde, H2C=S, and carbon disulfide, CS2, as the only products to be detected by their infrared spectra.Yet there is no sign of either CH3SH or H2C=S on photolysis of OCS in a CH4-doped argon matrix with the composition Ar:CH4:OCS = 100:20:1.Evidently the photolysis of OCS generates 1D sulfur atoms which add to an adjacent CH4 molecule with the formation of a vibrationally activated intermediate *; this relaxes to give CH3SH or decomposes to give H2C=S.Similar experiments have been carried out with solid argon matrices including OCS and either C2H4 or C2H2.In the presence of C2H4 there is no hint of C-H insertion; instead the C2H4 undergoes sulfur atom addition at the double bond to give thiirane, , as the sole product to be identified by its infrared spectrum.By contrast, C2H2 yields thioketene, H2C=S, ethynethiol, HCCSH, and carbon disulfide, CS2, as the main products, as well as thiirane, , as a minor product.The response of the hydrocarbon molecules in argon matrices can be interpreted in terms of the diffusion and reaction of ground-state 3P sulfur atoms but not of 1D sulfur atoms which are too short-lived to undergo significant migration.It appears that 3P sulfur atoms react with both C2H4 and C2H2 to yield a triplet diradical: that derived from C2H4 favors cyclization, whereas that derived from C2H2 rearranges preferentially to H2C=C=S and this in turn enters into secondary reactions to give HCCSH and CS2.