39891-55-9

Basic information

• Product Name: 3-BENZOFURANCARBOXYLIC ACID, 2,3-DIHYDRO-
• Synonyms: 3-BENZOFURANCARBOXYLIC ACID, 2,3-DIHYDRO-;2,3-Dihydro-3-benzofurancarboxylic acid;2,3-Dihydrobenzofuran-3-carboxylic acid;2,3-dihydro-1-benzofuran-3-carboxylic acid
• CAS NO: 39891-55-9
• Molecular Formula: C₉H₈O₃
• Molecular Weight: 164.15802
• Mol File: 39891-55-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 316.7±41.0 °C(Predicted)
• Appearance: /
• Density: 1.347±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.66±0.20(Predicted)
• CAS DataBase Reference: 3-BENZOFURANCARBOXYLIC ACID, 2,3-DIHYDRO-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BENZOFURANCARBOXYLIC ACID, 2,3-DIHYDRO-(39891-55-9)
• EPA Substance Registry System: 3-BENZOFURANCARBOXYLIC ACID, 2,3-DIHYDRO-(39891-55-9)

Safety Data

• Hazardous Substances Data: 39891-55-9(Hazardous Substances Data)

Usage

General Description

3-Benzofurancarboxylic acid, 2,3-dihydro- is a chemical compound with the molecular formula C9H8O3. It is a white to off-white crystalline powder that is insoluble in water but soluble in organic solvents. 3-BENZOFURANCARBOXYLIC ACID, 2,3-DIHYDRO- is used primarily in the pharmaceutical industry as an intermediate in the synthesis of various drugs and pharmaceuticals. It is also used in research and development as a building block for the creation of new chemical compounds. Additionally, 3-Benzofurancarboxylic acid, 2,3-dihydro- may have other potential industrial and research applications due to its chemical properties and structure.

Upstream product

• 26537-68-8 benzofurane-3-carboxylic acid 
• 39891-56-0 (rac)-methyl 2,3-dihydrobenzo[b]furan-3-carboxylate 
• 194278-43-8 benzofuran-3-carboxylic acid ethyl ester 
• 90-02-8 salicylaldehyde 
• 496-16-2 2.3-dihydrobenzofuran 
• 124-38-9 carbon dioxide 

Downstream Products

• 271-89-6 1-benzofurane 

Relevant articles and documents

Development of an enolate alkynylation approach towards the synthesis of the taiwanschirin natural products

Through the use of model studies, an approach was conceived towards the synthesis of the taiwanschirin family of natural products. These are structurally complex compounds which represent highly challenging and biologically active targets for total synthesis. This work describes a successful synthesis of the complex taiwanschirin fused [8,6,5] core through a novel alkynylation reaction coupled with an intramolecular Heck reaction used to construct the 8-membered ring.

Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use

The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the inventi

Further structure-activity relationships in the series of tropanyl esters endowed with potent antinociceptive activity

Several analogs of the α-tropanyl esters of 2-(4-chlorophenoxy)butyric acid (SM21) and 2-phenylthiobutyric acid (SM32), endowed with potent antinociceptive and cognition enhancing activity, were synthesized, aimed at obtaining more potent and safe drug candidates. Variation of the acyl moiety, as well as the conformational restriction of atropine to give the α-tropanyl ester of 2,3-dihydrobenzofurane-3-carboxylic acid (18), practically abolished activity. In the case of 18, the antimuscarinic activity was also severely affected by the conformation restrain. On the contrary, conformational restriction of phenoxybutyric and phenylthiobutyric acid derivatives to give the α-tropanyl ester of 2,3-dihydro-benzofurane-2-carboxylic acid and 2,3-dihydro-benzothiophene-2-carboxylic acid, afforded potent analgesic drugs that unfortunately were too toxic to be reliable drug candidates. A series of related esters of benzofurane-3-carboxylic acid and benzothiophene-3-carboxylic acid were also studied and found to be potent but toxic analgesics.