399-41-7

Basic information

• Product Name: (2-CHLORO-4-FLUOROPHENOXY)ACETIC ACID
• Synonyms: (2-chloro-4-fluorophenoxy)acetic acid(SALTDATA: FREE);2-(2-Chloro-4-fluorophenoxy)acetic acid;2-(2-chloro-4-fluoro-phenoxy)ethanoic acid
• CAS NO: 399-41-7
• Molecular Formula: C₈H₆ClFO₃
• Molecular Weight: 204.59
• Mol File: 399-41-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 321.6°Cat760mmHg
• Flash Point: 148.3°C
• Appearance: /
• Density: 1.453g/cm³
• Vapor Pressure: 0.000122mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (2-CHLORO-4-FLUOROPHENOXY)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2-CHLORO-4-FLUOROPHENOXY)ACETIC ACID(399-41-7)
• EPA Substance Registry System: (2-CHLORO-4-FLUOROPHENOXY)ACETIC ACID(399-41-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 399-41-7(Hazardous Substances Data)

Usage

General Description

(2-Chloro-4-fluorophenoxy)acetic acid is a synthetic chemical compound with the molecular formula C8H6ClFO3. It is a white to off-white crystalline powder with a molecular weight of 216.58 g/mol. (2-CHLORO-4-FLUOROPHENOXY)ACETIC ACID is often used as a herbicide or plant growth regulator in agricultural settings. It works by disrupting the growth of certain plants and weeds, making it an effective tool for controlling unwanted vegetation. The chemical is moderately toxic and may cause irritation to the skin, eyes, and respiratory system upon exposure. Additionally, it may pose environmental risks if not used and disposed of properly. Overall, (2-chloro-4-fluorophenoxy)acetic acid is a powerful and potentially hazardous substance with applications in agriculture and weed control.

InChI:InChI=1/C8H6ClFO3/c9-6-3-5(10)1-2-7(6)13-4-8(11)12/h1-3H,4H2,(H,11,12)/p-1

Upstream product

• 405-79-8 2-(4-fluorophenoxy)ethanoic acid 
• 1716-85-4 ethyl [(2-chloro-4-fluorophenyl)oxy]acetate 
• 1996-41-4 2-chloro-4-fluorophenol 
• 105-36-2 ethyl bromoacetate 
• 79-11-8 chloroacetic acid 

Downstream Products

• 826990-46-9 2-(2-chloro-4-fluorophenoxy)acetyl chloride 
• 826990-49-2 [(2-chloro-4-fluorophenoxyacetyl)(cyano)methylene]triphenylphosphorane 
• 826990-55-0 [(2-chloro-4-fluorophenoxyacetyl)(ethoxycarbonyl)methylene]triphenylphosphorane 
• 866145-53-1 O,O-dimethyl α-(2-chloro-4-fluorophenoxyacetoxy)benzylphosphonate 
• 866145-55-3 O,O-dimethyl α-(2-chloro-4-fluorophenoxyacetoxy)-3-nitrobenzylphosphonate 
• 1299293-64-3 O,O-dimethyl α(2-chloro-4-fluorophenoxyacetoxy)-2-hydroxybenzylphosphonate 
• 1395103-27-1 2-[(2-chloro-4-fluorophenoxy)acetoxy](furan-2-yl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 1395103-32-8 2-(2-chloro-4-fluorophenoxyacetoxy)(phenyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 1395103-34-0 2-(2-chloro-4-fluorophenoxyacetoxy)(methyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 1097936-08-7 2-methylpropan-2-aminium methyl (1-(2-(2-chloro-4-fluorophenoxy)acetoxy)ethyl)phosphonate 
• 1097936-10-1 2-methylpropan-2-aminium methyl (1-(2-(2-chloro-4-fluorophenoxy)acetoxy)propyl)phosphonate 
• 1097936-14-5 2-methylpropan-2-aminium methyl (1-(2-(2-chloro-4-fluorophenoxy)acetoxy)-2-methylpropyl)phosphonate 
• 1149672-86-5 C₁₃H₁₇ClFO₆P 
• 1149673-43-7 C₁₄H₁₉ClFO₆P 

Relevant articles and documents

Discovery, synthesis and biological characterization of a series of: N -(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1 H -pyrazol-5-yl)acetamide ethers as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of N-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1H-pyrazol-5-yl)acetamide ethers as G protein-gated inwardly-rectifying potassium (GIRK) channel activators. From our previous lead optimization efforts, we have identified a new ether-based scaffold and paired this with a novel sulfone-based head group to identify a potent and selective GIRK1/2 activator. In addition, we evaluated the compounds in tier 1 DMPK assays and have identified compounds that display nanomolar potency as GIRK1/2 activators with improved metabolic stability over the prototypical urea-based compounds. This journal is

Design and Synthesis of Novel 4-Hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one Derivatives for Use as Herbicides and Evaluation of Their Mode of Action

In order to develop a novel herbicide containing the β-triketone motif, a series of 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one derivatives were designed and synthesized. The bioassay results showed that compound II15 had good pre-emergent herbicidal activity even at a dosage of 187.5 g ha-1. Moreover, compound II15 showed a broader spectrum of weed control when compared with a commercial herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), and displayed good crop safety to Triticum aestivum L. and Zea mays Linn. when applied at 375 g ha-1 under pre-emergence conditions, which indicated its great potential as a herbicide. More importantly, studying the molecular mode of action of compound II15 revealed that the novel triketone structure is a proherbicide of its corresponding phenoxyacetic acid auxin herbicide, which has a herbicidal mechanism similar to that of 2,4-D. The present work indicates that the 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one motif may be a potential lead structure for further development of novel auxin-type herbicides.

An Efficient One-Pot Synthesis of 2-(Aryloxyacetyl)cyclohexane-1,3-diones as Herbicidal 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is an important target for new bleaching herbicides discovery. As a continuous work to discover novel crop selective HPPD inhibitor, a series of 2-(aryloxyacetyl)cyclohexane-1,3-diones were rationally designed and synthesized by an efficient one-pot procedure using N,N′-carbonyldiimidazole (CDI), triethylamine, and acetone cyanohydrin in CH2Cl2. A total of 58 triketone compounds were synthesized in good to excellent yields. Some of the triketones displayed potent in vitro Arabidopsis thaliana HPPD (AtHPPD) inhibitory activity. 2-(2-((1-Bromonaphthalen-2-yl)oxy)acetyl)-3-hydroxycyclohex-2-en-1-one, II-13, displayed high, broad-spectrum, and postemergent herbicidal activity at the dosage of 37.5-150 g ai/ha, nearly as potent as mesotrione against some weeds. Furthermore, II-13 showed good crop safety against maize and canola at the rate of 150 g ai/ha, indicating that II-13 might have potential as a herbicide for weed control in maize and canola fields. II-13 is the first HPPD inhibitor showing good crop safety toward canola.