826990-46-9

Basic information

• Product Name: (2-chloro-4-fluorophenoxy)acetyl chloride
• Synonyms: (2-chloro-4-fluorophenoxy)acetyl chloride;acetyl chloride, (2-chloro-4-fluorophenoxy)-;2-(2-chloro-4-fluorophenoxy)acetyl chloride
• CAS NO: 826990-46-9
• Molecular Formula: C₈H₅Cl₂FO₂
• Molecular Weight: 223
• Mol File: 826990-46-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 90-91 °C(Press: 12 Torr)
• Appearance: /
• Density: 1.442±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (2-chloro-4-fluorophenoxy)acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2-chloro-4-fluorophenoxy)acetyl chloride(826990-46-9)
• EPA Substance Registry System: (2-chloro-4-fluorophenoxy)acetyl chloride(826990-46-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 826990-46-9(Hazardous Substances Data)

Usage

Description

(2-chloro-4-fluorophenoxy)acetyl chloride is a chemical compound with the molecular formula C8H6ClFO2. It is a derivative of acetyl chloride, featuring a (2-chloro-4-fluorophenoxy) group attached. (2-chloro-4-fluorophenoxy)acetyl chloride is a valuable reagent in organic chemistry, known for its reactivity and potential hazards, which necessitates proper handling and safety precautions.

Uses

Used in Pharmaceutical Synthesis:
(2-chloro-4-fluorophenoxy)acetyl chloride is used as an intermediate in the synthesis of various pharmaceuticals. It serves to introduce the (2-chloro-4-fluorophenoxy)acetyl group into other molecules, enabling the creation of new compounds with specific properties and functions that can be utilized in medicinal applications.
Used in Agrochemical Production:
In the agrochemical industry, (2-chloro-4-fluorophenoxy)acetyl chloride is also used as an intermediate. It aids in the development of new agrochemicals by incorporating the desired acetyl group into molecules to enhance their effectiveness in agricultural applications.
Used in Organic Chemistry Research:
As a reagent in organic chemistry, (2-chloro-4-fluorophenoxy)acetyl chloride is used to explore and expand the understanding of chemical reactions and mechanisms. Its unique properties allow researchers to modify and study the behavior of various organic compounds in different chemical contexts.

Upstream product

• 399-41-7 2-(2-chloro-4-fluorophenoxy)acetic acid 
• 1996-41-4 2-chloro-4-fluorophenol 
• 1716-85-4 ethyl [(2-chloro-4-fluorophenyl)oxy]acetate 

Downstream Products

• 826990-49-2 [(2-chloro-4-fluorophenoxyacetyl)(cyano)methylene]triphenylphosphorane 
• 826990-55-0 [(2-chloro-4-fluorophenoxyacetyl)(ethoxycarbonyl)methylene]triphenylphosphorane 
• 866145-53-1 O,O-dimethyl α-(2-chloro-4-fluorophenoxyacetoxy)benzylphosphonate 
• 866145-55-3 O,O-dimethyl α-(2-chloro-4-fluorophenoxyacetoxy)-3-nitrobenzylphosphonate 
• 1299293-64-3 O,O-dimethyl α(2-chloro-4-fluorophenoxyacetoxy)-2-hydroxybenzylphosphonate 
• 1357284-98-0 O,O'-dibutyl {[2-(2-chloro-4-fluorophenoxy)acetamido](phenyl)methyl}phosphonate 
• 1395103-32-8 2-(2-chloro-4-fluorophenoxyacetoxy)(phenyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 1395103-34-0 2-(2-chloro-4-fluorophenoxyacetoxy)(methyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 1395103-27-1 2-[(2-chloro-4-fluorophenoxy)acetoxy](furan-2-yl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 1097936-08-7 2-methylpropan-2-aminium methyl (1-(2-(2-chloro-4-fluorophenoxy)acetoxy)ethyl)phosphonate 
• 1097936-10-1 2-methylpropan-2-aminium methyl (1-(2-(2-chloro-4-fluorophenoxy)acetoxy)propyl)phosphonate 
• 1149672-86-5 C₁₃H₁₇ClFO₆P 
• 1097936-14-5 2-methylpropan-2-aminium methyl (1-(2-(2-chloro-4-fluorophenoxy)acetoxy)-2-methylpropyl)phosphonate 
• 1149673-43-7 C₁₄H₁₉ClFO₆P 

Relevant articles and documents

Synthesis of 3-(1-aminoethylene)-6-methylpyran-2, 4-dione derivatives and application thereof as herbicides

The invention relates to synthesis and application of 3-(1-aminoethylene)-6-methylpyran-2, 4- dione derivatives. The structural formula of the derivative is shown in the specification. The structuralgeneral formula of the compound is (I), wherein R and R1

Herbicidal activity and application cyclic of phosphonates

Among alkylphosphonates Io,O,O-dimethyl 1-(2,4-dichlorophenoxyacetoxy) ethylphosphonate (clacyfos) was found to be an effective inhibitor against dicotyledons PHDc and exhibited excellent herbicidal activity in our previous work. According to our study on the alkylphosphonates Io, both R1 and R2 groups in the structural unit of phosphorus-containing played a very important role in herbicidal activity. Therefore, a series of 2-[1-(substituted phenoxycarboxy)alkyl]-5,5-dimethyl-1,3,2-dioxaphosphinane-2-one containing fluorine II was obtained by the modification of alkylphosphonates Io. The bioassay results showed that cyclic phosphonate II-6 with CH3 as R, 2-Cl,4-F as Yn exhibited promising herbicidal activity. Its herbicidal activity, weed-controlling spectrum, selectivity between crops and weeds were further evaluated in greenhouse and field.

Synthesis and Biological Activity of Ethyl 4-Alkyl-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylate

(Chemical Equation Presented) A series of novel ethyl 4-(methyl or trifluoromethyl)-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylates 7a, 7b, 7c, 7d, 7e and 8f, 8g, 8h, 8i, 8j, 8k, 8l, 8m, 8n, 8o, 8p, 8q, 8r were synthesized, and their structures were confirmed by IR, 1H-NMR, MS spectra and elemental analysis. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal activities. Compared with the fluorine free compounds 7a, 7b, and 7e, the compounds bearing fluorine 8g, 8j, and 8q showed higher herbicidal activities with 70-100% inhibition against Capsella bursa-pastoris, Amaranthus restroflexus, and Eclipta prostrata at the dosage of 150 g/ha, which indicated that the trifluoromethyl on the thiazole ring was beneficial for the herbicidal activity. Furthermore, compounds 8f, 8g, 8h, 8i, 8j, 8k, 8l, 8m, 8n, 8o, 8p, 8q, 8r were tested for fungicidal activity against Pseudoperonospora cubensis at 500 μg/mL. Compounds 8f and 8q showed the best fungicidal activity with more than 80% inhibition.