399041-11-3Relevant articles and documents
Catalytic, asymmetric Mannich-type reactions of N-acylimino esters for direct formation of N-acylated amino acid derivatives. Efficient synthesis of a novel inhibitor of ceramide trafficking, HPA-12.
Kobayashi, Shu,Matsubara, Ryosuke,Kitagawa, Hidetoshi
, p. 143 - 145 (2002)
[reaction: see text] Catalytic, enantioselective Mannich-type reactions of N-acylimino esters for direct formation of N-acylated amino acid derivatives are described. A chiral copper catalyst prepared from Cu(OTf)(2) and a chiral diamine ligand is used. A
A straightforward synthesis of the CERT inhibitor (1′R,3′S)-HPA-12
Abad, José-Luis,Armero, Iván,Delgado, Antonio
, p. 1706 - 1708 (2015/03/14)
A straightforward synthesis of the CERT inhibitor HPA-12, (1′R,3′S)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide, is reported. The method requires only five synthetic steps from commercially available d-aspartic acid and leads to enantiopure HPA-12 in good overall yields.
Copper(II)-catalyzed highly enantioselective addition of enamides to imines: The use of einamides as nucleophiles in asymmetric catalysis
Matsubara, Ryosuke,Nakamura, Yoshitaka,Kobayashi, Shu
, p. 1679 - 1681 (2007/10/03)
High-yielding efficient routes to optically active amino acid and 1,3-diamine derivatives have been achieved by the catalytic enantioselective addition of enamides to imines using a chiral copper catalyst (see scheme). This reaction demonstrates the utili
