40054-40-8

Basic information

• Product Name: 5-(O-CHLOROPHENYL)-7-ETHYL-1,2-DIHYDRO-3H-THIENO[2,3-E][1,4]DIAZEPINE-2-THIONE
• Synonyms: 5-(O-CHLOROPHENYL)-7-ETHYL-1,2-DIHYDRO-3H-THIENO[2,3-E][1,4]DIAZEPINE-2-THIONE;(E)-5-(2-CHLOROPHENYL)-7-ETHYL-1H-THIENO[2,3-E][1,4]DIAZEPINE-2(3H)-THIONE;5-(2-Chlorophenyl)-7-ethyl-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepine-2-thione;5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepin-2-thione
• CAS NO: 40054-40-8
• Molecular Formula: C₁₅H₁₃ClN₂S₂
• Molecular Weight: 320.867
• Mol File: 40054-40-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 198-199℃
• Boiling Point: 438.6±55.0 °C(Predicted)
• Appearance: /
• Density: 1.39
• PKA: 9.99±0.40(Predicted)
• CAS DataBase Reference: 5-(O-CHLOROPHENYL)-7-ETHYL-1,2-DIHYDRO-3H-THIENO[2,3-E][1,4]DIAZEPINE-2-THIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(O-CHLOROPHENYL)-7-ETHYL-1,2-DIHYDRO-3H-THIENO[2,3-E][1,4]DIAZEPINE-2-THIONE(40054-40-8)
• EPA Substance Registry System: 5-(O-CHLOROPHENYL)-7-ETHYL-1,2-DIHYDRO-3H-THIENO[2,3-E][1,4]DIAZEPINE-2-THIONE(40054-40-8)

Safety Data

• Hazardous Substances Data: 40054-40-8(Hazardous Substances Data)

Usage

General Description

5-(O-chlorophenyl)-7-ethyl-1,2-dihydro-3H-thieno[2,3-e][1,4]diazepine-2-thione is a chemical compound that belongs to the thienodiazepine class of drugs. It is a thienodiazepine derivative with an O-chlorophenyl group and an ethyl group attached to the 7th position of the diazepine ring, and a thione group attached to the 2nd position. 5-(O-CHLOROPHENYL)-7-ETHYL-1,2-DIHYDRO-3H-THIENO[2,3-E][1,4]DIAZEPINE-2-THIONE has various pharmacological properties, including sedative, anxiolytic, and muscle relaxant effects, and has been studied for its potential use in the treatment of anxiety, insomnia, and other central nervous system disorders. Additionally, it may also have anticonvulsant and hypnotic properties. Further research is needed to fully understand the potential therapeutic applications and safety profile of this compound.

Upstream product

• 33671-37-3 5-(2-Chlorophenyl)-7-ethyl-1,3-dihydro-2H-thieno[2,3-e]1,4-diazepin-2-one 

Downstream Products

• 67727-30-4 5-(2-chloro-phenyl)-7-ethyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one propionylhydrazone 
• 54905-10-1 1-[4-(2-chloro-phenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-ethanone 
• 41740-71-0 5-(2-chloro-phenyl)-7-ethyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one benzoylhydrazone 
• 40054-68-0 4-(2-chlorophenyl)-2-ethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine 
• 40054-69-1 etizolam 
• 40054-72-6 5-(2-chloro-phenyl)-7-ethyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one acetylhydrazone 
• 58066-32-3 4-(2-chloro-phenyl)-2,9-diethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine 
• 40054-85-1 2-ethyl-4-(2-chloro-phenyl)-9-phenyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine 

Relevant articles and documents

Therapeutic agent for osteoporosis and diazepine compound

A therapeutic agent for osteoporosis, comprising an azepine compound of the formula STR1 wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof as an active ingredient, a method for treating osteoporosis comprising administering said compound and a use of said compound for the production of a therapeutic agent for osteoporosis. The compounds of the formula (I) have superior bone resorption-inhibitory activity and act to reduce the increased amount of calcium in blood serum, which is caused by bone resorption. Accordingly, these compounds are usable as pharmaceutical agents to effectively inhibit bone resorption, to prevent decrease of bone mass and to prevent or suppress the increase of calcium amount in blood serum which is caused by the progress of bone resorption, with regard to Paget's disease, hypercalcemia, osteoporosis and so on in which the progress of bone resorption is considered to be deeply associated with the symptom, and to the symptoms of progressing bone resorption (development into osteoporosis) along with inflammatory joint diseases such as rheumatoid arthritis.

Syntheses and structure-activity relationships of 6-Aryl-4H-s-triazolo[3,4-c]thieno[2,3-e][1,4]diazepines

A variety of 6 aryl 4H s triazolo [3,4-c]thieno [2,3-e] [1,4]diazepines was synthesized and tested for anti-pentylenetetrazole activity and inhibition of fighting episodes. The structure-activity relationships are discussed. Some compounds were more active than diazepam in the two assays. Among them, 6 (o chlorophenyl) 8 ethyl 1 methyl 4H s triazolo [3,4-c] thieno [2,3-e][1,4] diazepine was found to have favourable properties as an anxiolytic drug with very low toxicity. Clinical studies of this compound (Y-7131) are under way.