40054-69-1 Usage
Description
Etizolam, a thienodiazepine benzodiazepine derivative, is a potent anxiolytic with amnesic, anxiolytic, anticonvulsant, hypnotic, sedative, and skeletal muscle relaxant properties. It acts on the benzodiazepine site of the GABA-A receptor as an agonist, increasing inhibitory GABAergic transmission throughout the central nervous system. Etizolam is closely related to brotizolam and pharmacologically resembles diazepam. It is also known to have an effect on monoamine metabolism in the brain.
Uses
Used in Pharmaceutical Industry:
Etizolam is used as a short-term treatment for insomnia, anxiety, or panic attacks due to its anxiolytic, sedative, and muscle relaxant properties.
Used in Nasal Dilator Applications:
Etizolam is used as a nasal dilator for its muscle relaxant properties, which can help alleviate nasal congestion and improve breathing.
References
https://www.drugbank.ca/drugs/DB09166
https://en.wikipedia.org/wiki/Etizolam
Casacchia, Massimo, F. Bolino, and U. Ecari. "Etizolam in the treatment of generalized anxiety disorder: a double-blind study versus placebo."Current Medical Research & Opinion 12.4(2008):215-223.
Savoldi, F, G. Somenzini, and U. Ecari. "Etizolam versus placebo in the treatment of panic disorder with agoraphobia: a double-blind study."Current Medical Research & Opinion 12.3(1990):185.
Hirashima, Y, et al. "Etizolam, an anti-anxiety agent, attenuates recurrence of chronic subdural hematoma--evaluation by computed tomography." Neurologia medico-chirurgica 42.2(2002):53-55.
Originator
Yoshitomi (Japan)
Check Digit Verification of cas no
The CAS Registry Mumber 40054-69-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,0,5 and 4 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 40054-69:
(7*4)+(6*0)+(5*0)+(4*5)+(3*4)+(2*6)+(1*9)=81
81 % 10 = 1
So 40054-69-1 is a valid CAS Registry Number.
InChI:InChI=1/C17H15ClN4S/c1-3-11-8-13-16(12-6-4-5-7-14(12)18)19-9-15-21-20-10(2)22(15)17(13)23-11/h4-8H,3,9H2,1-2H3
40054-69-1Relevant articles and documents
Syntheses and structure-activity relationships of 6-Aryl-4H-s-triazolo[3,4-c]thieno[2,3-e][1,4]diazepines
Tahara,Araki,Shiroki,Matsuo,Munakata
, p. 1153 - 1158 (2007/10/08)
A variety of 6 aryl 4H s triazolo [3,4-c]thieno [2,3-e] [1,4]diazepines was synthesized and tested for anti-pentylenetetrazole activity and inhibition of fighting episodes. The structure-activity relationships are discussed. Some compounds were more active than diazepam in the two assays. Among them, 6 (o chlorophenyl) 8 ethyl 1 methyl 4H s triazolo [3,4-c] thieno [2,3-e][1,4] diazepine was found to have favourable properties as an anxiolytic drug with very low toxicity. Clinical studies of this compound (Y-7131) are under way.