401518-16-9

Basic information

• Product Name: ethyl [4-cyano-4-(3-ethoxy-4-methoxyphenyl)piperidin-1-yl]acetate
• Synonyms: ethyl [4-cyano-4-(3-ethoxy-4-methoxyphenyl)piperidin-1-yl]acetate
• CAS NO: 401518-16-9
• Molecular Weight: 346.426
• Mol File: 401518-16-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl [4-cyano-4-(3-ethoxy-4-methoxyphenyl)piperidin-1-yl]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl [4-cyano-4-(3-ethoxy-4-methoxyphenyl)piperidin-1-yl]acetate(401518-16-9)
• EPA Substance Registry System: ethyl [4-cyano-4-(3-ethoxy-4-methoxyphenyl)piperidin-1-yl]acetate(401518-16-9)

Safety Data

• Hazardous Substances Data: 401518-16-9(Hazardous Substances Data)

Upstream product

• 105-36-2 ethyl bromoacetate 
• 103796-99-2 (3-ethoxy-4-methoxy-phenyl)-acetonitrile 
• 666179-95-9 tert-butyl 4-cyano-4-(3-ethoxy-4-methoxyphenyl)piperidine-1-carboxylate 
• 666180-05-8 4-(3-ethoxy-4-methoxy-phenyl)-piperidine-4-carbonitrile 

Downstream Products

• 401518-38-5 2-(4-(3-ethoxy-4-methoxyphenyl)-4-cyanopiperidin-1-yl)acetic acid 

Relevant articles and documents

Highly potent PDE4 inhibitors with therapeutic potential

Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of

Highly potent PDE4 inhibitors with therapeutic potential

Synthesis and biological evaluation of piperidine derivatives is reported. The hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system prompted us to design and synthesize a hydrophilic piperidine