666180-05-8Relevant articles and documents
Highly potent PDE4 inhibitors with therapeutic potential
Ochiai, Hiroshi,Ohtani, Tazumi,Ishida, Akiharu,Kusumi, Kensuke,Kato, Masashi,Kohno, Hiroshi,Kishikawa, Katuya,Obata, Takaaki,Nakai, Hisao,Toda, Masaaki
, p. 207 - 210 (2007/10/03)
Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of