401580-43-6

Basic information

• Product Name: 5-(4-fluorophenyl)-3-phenyl-1,2,4-oxadiazole
• Synonyms: 5-(4-fluorophenyl)-3-phenyl-1,2,4-oxadiazole
• CAS NO: 401580-43-6
• Molecular Weight: 240.237
• Mol File: 401580-43-6.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 5-(4-fluorophenyl)-3-phenyl-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-fluorophenyl)-3-phenyl-1,2,4-oxadiazole(401580-43-6)
• EPA Substance Registry System: 5-(4-fluorophenyl)-3-phenyl-1,2,4-oxadiazole(401580-43-6)

Safety Data

• Hazardous Substances Data: 401580-43-6(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 932-90-1 Benzaldoxime 
• 698-16-8 benzohydroximoyl chloride 
• 459-57-4 4-fluorobenzaldehyde 
• 613-92-3 N-hydroxybenzenecarboximidamide 
• 140-75-0 para-fluorobenzylamine 
• 100-47-0 benzonitrile 
• 352-32-9 p-fluorotoluene 
• 6425-24-7 1-(dibromomethyl)-4-fluorobenzene 
• 613-92-3 N-hydroxyl-benzamidine 
• 456-22-4 4-Fluorobenzoic acid 
• 1670-14-0 benzamidine monohydrochloride 
• 658-13-9 p-fluorobenzoyl cyanide 
• 1166388-66-4 benzyl-O-4-fluorobenzamidoxime 

Relevant articles and documents

Electrochemical synthesis of 1,2,4-oxadiazoles from amidoximes through dehydrogenative cyclization

A convenient and efficient method for the generation of the iminoxy radical through anodic oxidation was developed for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles fromN-benzyl amidoximes. The transformation proceeds through 1.5-Hydrogen Atom Transfer (1,5-HAT) and intramolecular cyclization. The process features simple operation, mild conditions, broad substrate scope and high functional group compatibility, and provides a facile and practical way for the preparation of 1,2,4-oxadiazoles.

Copper-Catalyzed Three-Component Cascade Reaction of Benzaldehyde with Benzylamine and Hydroxylamine or Aniline: Synthesis of 1,2,4-Oxadiazoles and Quinazolines

The analogous three-component synthesis strategy for substituted 1,2,4-oxadiazole and quinazoline derivatives from readily available benzaldehyde, benzylamine and hydroxylamine or aniline has been developed. Both the cascade reaction sequences involves nucleophilic addition of C?N bond, introduction a halogen donor, nucleophilic substitution and Cu(II)-catalyzed aerobic oxidation. This synthesis methodology demonstrated good yields, broad substrate scope and oxygen as a green oxidant. Thus, this synthesis protocol provides strategies for the construction of substituted 1,2,4-oxadiazole and quinazolines from readily and simple starting materials. (Figure presented.).

NBS-mediated practical cyclization of N-acyl amidines to 1,2,4-oxadiazoles via oxidative N?O bond formation

A reaction involving an efficient NBS-mediated oxidative N?O bond formation has been established for the synthesis of 1,2,4-oxadiazoles from readily accessible N-acyl amidines. The features of this synthetic method include simplicity of operation, mild re